EAGER: PAN-VARIANT COVID-19 DIFFERENTIATED BIOSENSING USING GRAPHENE FIELD-EFFECT SENSORS

热切：泛变种新冠肺炎使用石墨烯场效应场效应实现差异化生物传感非技术：新冠肺炎引发的流行病引发了对能够快速检测传染病的便携式快速生物传感器的科学研究需求不断增加。随着除原始新冠肺炎毒株之外的变种的兴起，需要科学地理解和开发能够迅速适应于检测现有的、正在出现的和新的变种的生物传感器。该奖项将研究简便、精确、多路复用的生物传感器，用于从基于先进纳米材料的不同进化变体中检测病毒，即功能化石墨烯场效应管，它具有在低成本平台中具有前所未有的灵敏度和快速响应时间的潜力。技术：这项研究旨在开创一个基于功能化石墨烯-抗体选择性相互作用的快速多变体检测的单一平台，该平台提供了较高的固有检测极限。不同的新冠肺炎变体将使用抗体功能化的石墨烯场效应传感平台进行评估。这项研究的结果将通过结构和概念工程产生关于多变量生物传感、检测极限和交叉反应的新知识。传感器平台具有足够的通用性，可以检测现有的、新兴的和未来的变体。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

EAGER: PAN-VARIANT COVID-19 DIFFERENTIATED BIOSENSING USING GRAPHENE FIELD-EFFECT SENSORSNontechnical:The pandemic due to COVID-19 has triggered an increasing demand for scientific research into portable fast biosensors capable of rapid infectious disease detection. With the rise of variants beyond the original COVID-19 strain, there is a need for the scientific understanding and development of biosensors that can be rapidly adapted to sense existing, emerging and new variants of the virus. This award will investigate facile, precise, multiplexed biosensors for detection of the virus from the different evolving variants based on advanced nanomaterials, namely, functionalized graphene field-effect transistors that has the potential for unprecedented sensitivity and a fast response time in a low-cost platform.Technical:This research aims to pioneer a single platform for rapid multi-variant detection based on functionalized graphene-antibody selective interaction that affords a high intrinsic limit of detection. Different variants of Covid-19 will be evaluated with the antibody-functionalized graphene field-effect sensing platform. The outcomes of this research will generate new knowledge on multi-variant biosensing, limits of detection, and cross-reactivity through structural and conceptual engineering. The sensor platform is sufficiently versatile to be adapted to detect both existing, emerging, and future variants.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.