The functional organisation of the trans-Golgi network: From cultured cells to physiological systems

这项研究将有助于更好地了解所有真核细胞的分泌途径，这是一个具有广泛生物学和生物医学意义的过程。它将在最广泛的意义上影响细胞生物学，从膜生物发生到脂质结构域组织，以及膜运输，蛋白质结构和蛋白质靶向。此外，本工作将利用和发展活细胞成像和RNA干扰的前沿技术作为研究蛋白质家族功能的遗传工具。通过培养研究生和博士后人员，它将为澳大利亚的细胞生物学专业知识做出贡献。国际合作将加强澳大利亚与海外研究的联系。

This research will result in a better understanding of the secretory pathway of all eukaryotic cells, a process of broad biological and biomedical significance. It will impact on cell biology in the broadest sense, from membrane biogenesis to lipid domain organization, as well as membrane transport, protein structure and protein targeting. Furthermore, this work will utilize and develop frontier technologies of live cell imaging and RNA interference as a genetic tool to investigate functions of a protein family. By training post-graduate students and post-doctoral staff, it will contribute to the expertise of cell biology in Australia. International collaborations will enhance connections between Australia and overseas research.