Dual nanoparticles to distinguish between right and left biomolecules

本项目旨在提高光学活性对超低分子浓度样品的灵敏度。旋光性是一种商业上可用的技术，用于区分化学上相同和形态上不同的生物分子（对映体）。与其他散射技术不同，光学活性的近场增强尚未实现，因此限制了这些测量的高分子浓度。有证据表明，使用双纳米颗粒（即对电场和磁场具有相同响应的小颗粒）可以增强光学活性。该项目旨在提高我们对这些双纳米粒子的理解，并通过实验实现它们用于增强光学活性。

This project aims to enhance the sensitivity of optical activity to ultralow molecular concentration samples. Optical activity is a commercially available technique used to distinguish chemically identical and morphologically different biomolecules (enantiomers). Unlike other scattering techniques, near-field enhancing of optical activity has not been achieved, thus limiting these measurements to high molecular concentrations. There is evidence indicating that optical activity can be enhanced using dual nanoparticles (ie small particles with the same response to electric and magnetic fields). This project aims to advance our understanding of these dual nanoparticles and experimentally implement their use to enhance optical activity.