Nanoprobe and Microprobe Structural and Spectroscopic Studies in Biomedical Research
Nanoprobe and Microprobe Structural and Spectroscopic Studies in Biomedical Research
批准号:
DP0664706
负责人:
Prof Peter Lay
金额:
$23.68万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2006
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2006-02-02 至 2008-11-27
中文摘要
突破性的微探针和纳米探针技术,包括X射线、可见光和红外光,可以聚焦到哺乳动物细胞的不同成分,以询问其中发生的生物化学。每一种不同波长的光都提供了互补的生化信息,使药物治疗和疾病过程中细胞发生变化的多层信息成为可能。这将提供有关药物去向以及它们在细胞内如何转化的前所未有的信息,进而可能彻底改变具有更高特异性和更低副作用的新药的设计方式。
英文摘要
Breakthrough microprobe and nanoprobe technologies, involving X-ray, visible and infrared light can focus into different components of mammalian cells in order to interrogate the biochemistry that is occurring therein. Each of the different wavelengths of light provides complementary biochemical information that enables multi-layered information on changes in cells that occur as a function of drug treatments and disease processes. This will provide unprecedented information as to where drugs go and how they are transformed inside cells that, in turn, may revolutionalise the way in which new drugs are designed that have higher specificity and lower side effects.
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会议论文
Metal Virulence and Therapeutic Factors in Pathogen Bioinorganic Chemistry
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批准号:DP210101632
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项目类别:Discovery Projects
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资助金额:$42.2万
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财政年份:2021
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负责人:Prof Peter Lay
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依托单位:
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies
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批准号:LE200100043
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$25.94万
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财政年份:2020
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负责人:Prof Peter Lay
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依托单位:
Bioinorganic chemistry between immune cell and pathogen
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批准号:DP180102741
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项目类别:Discovery Projects
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资助金额:$37.48万
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财政年份:2018
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负责人:Prof Peter Lay
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依托单位:
Roles of Metal Complexes in Carbohydrate Metabolism – Anti-Diabetic Drugs
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批准号:DP160104172
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项目类别:Discovery Projects
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资助金额:$34.92万
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财政年份:2016
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负责人:Prof Peter Lay
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依托单位:
Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies
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批准号:DP140100176
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项目类别:Discovery Projects
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资助金额:$36.31万
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财政年份:2014
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负责人:Prof Peter Lay
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依托单位:
The roles of metal complexes and related metalloproteins in the essential and therapeutic control of diabetes
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批准号:DP130103566
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项目类别:Discovery Projects
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资助金额:$31.98万
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财政年份:2013
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负责人:Prof Peter Lay
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依托单位:
Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons
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批准号:LE110100174
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$53.34万
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财政年份:2011
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负责人:Prof Peter Lay
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依托单位:
Design and Mechanistic Studies of Metal-Based Anti-Diabetic Drugs
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批准号:DP1095310
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项目类别:Discovery Projects
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资助金额:$31.35万
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财政年份:2010
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负责人:Prof Peter Lay
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依托单位:
Microprobe and Nanoprobe Studies on Intracellular Disease Processes and Their Treatment
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批准号:DP0984722
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项目类别:Discovery Projects
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资助金额:$70.59万
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财政年份:2009
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负责人:Prof Peter Lay
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依托单位:
Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research
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批准号:LE0883036
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$26.67万
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财政年份:2008
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负责人:Prof Peter Lay
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依托单位:
Biomolecular chemical survival strategies of terrestrial extremophiles and the spectroscopic search for life on Mars
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批准号:LX0776464
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项目类别:Linkage - International
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资助金额:$2.68万
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财政年份:2007
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负责人:Prof Peter Lay
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依托单位:
The roles of metal ions in glucose metabolism and the treatment of diabetes
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批准号:DP0774173
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项目类别:Discovery Projects
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资助金额:$27.35万
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财政年份:2007
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负责人:Prof Peter Lay
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依托单位:
Vibrational Spectroscopy Microprobe/FESEM/AFM Imaging of Cells, Tissues and Materials
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批准号:LE0560680
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$60.14万
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财政年份:2005
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负责人:Prof Peter Lay
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依托单位:
Metals in Medicine
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批准号:SR0354474
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项目类别:Special Research Initiatives
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资助金额:$2.0万
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财政年份:2004
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负责人:Prof Peter Lay
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依托单位:
Metal-Based Anti-inflammatory Drugs with High Efficacy and Low Side-Effects
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批准号:LP0453765
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项目类别:Linkage Projects
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资助金额:$24.47万
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财政年份:2004
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负责人:Prof Peter Lay
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依托单位:
Nanoprobe and Microprobe Spectroscopic Techniques in Drug Design, Probing Mechanisms of Diseases, and Bioinorganic Chemistry
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批准号:DP0346162
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项目类别:Discovery Projects
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资助金额:$19.24万
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财政年份:2003
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负责人:Prof Peter Lay
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依托单位:
Fluorescence Detector for the Australian National Beamline Facility
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批准号:LE0346515
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$33.81万
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财政年份:2003
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负责人:Prof Peter Lay
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依托单位:
The Chemistry and Biochemistry of Chromium: Cancer and Nutrition
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批准号:DP0208409
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项目类别:Discovery Projects
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资助金额:$70.17万
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财政年份:2002
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负责人:Prof Peter Lay
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依托单位:
海外基金