Examination of signaling pathway specific to oral mucosa wound healing.- Difference between oral mucosa and epidermis -

口腔黏膜的愈合速度快于皮肤，伤口愈合过程中口腔黏膜的瘢痕形成也比皮肤少。我们试图通过内在的细胞生物学特性来探索口腔角质形成细胞和表皮角质形成细胞在体外的这些差异。通过药理手段激活PI3kinase信号通路。采用划痕实验（体外伤口愈合实验），检测细胞运动和与PI3kinase相关的蛋白表达。在本研究中使用的试剂没有引起任何显著差异。

Oral mucosa heals faster than does skin, and scar formation during the wound healing in oral mucosa is also less than that in skin. We attempted to explore these differences between oral keratinocytes and epidermal keratinocytes in vitro by intrinsic cellular, biological characteristics. PI3kinase signaling pathway was activated by using a pharmacological means. Using a scratch assay (in vitro wound healing assay), cell motility and protein expressions related to PI3kinase were examined. Those reagents used in this study did not induce any significant differences.