Pathological study of AA amyloidosis in vaccinated white hens and

已知蛋鸡群中系统性淀粉样变性的爆发是由多次接种油乳化的白蛋白引起的反复炎症刺激引起的。在一个大型家禽养殖场的接种生长鸡中观察到致命性AA淀粉样变性的爆发。在对死母鸡的熔化后检查中观察到淀粉样沉积物，这表明肠道沙门氏菌（SE）疫苗接种被认为是AA淀粉样变性发展的潜在风险。为了确定鸡AA淀粉样变性在白色母鸡中的传播，我们通过静脉内或口服给予鸡AA原纤维在接种疫苗的鸡中诱导实验性AA淀粉样变性。在注射SE和静脉注射和口服鸡AA纤维的鸡中观察到淀粉样沉积。这些结果表明，鸡AA淀粉样变性可以通过疫苗接种诱导，并可能在种间传播。

Outbreaks of systemic amyloidosis in flocks of layers are known to be induced by repeated inflammatory stimulation with multiple vaccinations with oil-emulsified bacterins. Outbreaks of fatal AA amyloidosis were observed in vaccinated growing chickens in a large scale poultry farm. Amyloid deposits were observed in postmolten examination of dead hens, suggesting that vaccinations with Salmonella Enteritidis (SE) would be considered as a potential risk for the development of AA amyloidosis. To determine the transmission of chicken AA amyloidosis among white hens, we induced experimental AA amyloidosis in vaccinated chickens by intravenous or oral administration of chicken AA fibrils. Amyloid deposits were observed in chickens ingected with SE and inouculated with chicken AA fibrils intravenously and orally. These results suggest that chicken AA amyloidosis can be induced by vaccinations, and may be transmitted among species.