Pathogenesis of influenza virus-associated encephalopathy of childhood induced in animal model

在本研究中，我证明了流感病毒（IFV）感染乳鼠肺增强脑病和高细胞因子血症，由于脂多糖（LPS）接种，脑病理学，高细胞因子血症和缺乏IFV治疗的动物模型的脑IFV和LPS是类似的IFV相关的脑病的儿童。提示血管内皮细胞和星形胶质细胞的凋亡导致血脑屏障通透性增加可能是IFV相关脑病的主要致病因素。

In the present study, I demonstrated that influenza virus (IFV) infection to the lungs of suckling mice enhanced encephalopathy and hypercytokinemia due to lipopolysaccharide (LPS) inoculation, and brain pathology, hypercytokinemia and absence of IFV in the brain of the animal model treated with IFV and LPS were similar to IFV-associated encephalopathy of childhood. Furthermore, it was suggested from the present study that the apoptosis of vascular endothelial cell and astrocytes causing increased permeability of blood brain barrier might be the major contributing factor forIFV-associated encephalopathy of childhood.