Biodegradation of Composite Materials Consisting of High Strength Polymeric Fibers for the Development of Artificial Ligament

1.为了开发人造韧带，我们设计了以尼龙或涤纶纱线为核心，以两根螺旋交叉缠绕的Twaron纱线为鞘的复合线。对复合线进行了生理盐水浸泡和疲劳试验以及大鼠皮肤下植入试验。结果表明，以涤纶为芯纱的缠绕Twaron纱线每米500转组成的PET500具有设计人工韧带的可能性。2.对PET500进行了更详细的研究，包括在胆固醇-脂溶液中的疲劳实验和兔在体疲劳实验中植入的材料。体外和体内的循环变形均表明，PET500的强度和伸长率有所下降，但硬度没有变化。3.未检测到PET500的细胞毒性。4.然后，将20-28股PET500缠绕制成候选人工韧带，并对其拉伸性能进行了研究。其强度和刚度均大于人前十字韧带。需要进一步的体外和体内研究来评估候选材料。

1.For the development of artifical ligament, we designed composite threads consisting of nylon or polyester yarn as the core and two spirally cross-wound Twaron yarns as the sheath. Immersion and fatigue tests in a saline solution as well as implantation under rat skin were performed on the composite threads. The results showed that PET500 composed of 500 turns of wound Twaron yarns per meter with polyester as the core yarn has a possibility for the design of an artificial ligament.2.More detailed studies on PET500 were done by the fatigue test in a cholesterol-lipid solution and the in vivo fatigue test with the material implanted between the patella and tibia in the rabbit. Both tests showed that the in vitro and in vivo cyclic deformation decreased strength and elongation, but did not change stiffness.3.Cytotoxicity of PET500 was not detected.4.Then, 20-28 strands of the composite PET500 were twisted to fabricate a candidate of an artificial ligament, and their tensile properties were studied. Their strength and stiffness were larger than those of the human anterior cruciate ligament (ACL). Further in vitro and in vivo studies are needed to evaluate the candidate material.