Regulation of bone morphogeretic protein activity by additional cytokines

为了测试骨形态发生蛋白（BMP）的活性是否可能受到细胞因子的调节，我们建立了一个研究模型来研究细胞因子对人骨BMP活性的影响。在本研究过程中，我们检查了以下内容，即；1. 2.其他细胞因子调节BMP活性的可能性；2 .实验动物人骨形成的可能性。3 .实验动物正常成骨的可能性；BMP诱导人骨组织成骨的可能性。从这些检查中，澄清了以下几点，即1。BMP活性可受其他细胞因子的影响。C.B-17/Icr-scid/scid （C.B-17 scid）小鼠在人骨移植后至少4个月可以观察到人骨形成。3 .与正常对照小鼠相比，C.B-17 scid小鼠骨形成正常；在C.B-17 scid小鼠移植的人骨上，可以观察到BMP注射诱导的新生骨。综上所述，移植人骨的c - b -17 scid小鼠可能是分析细胞因子对人骨BMP活性影响的潜在工具。

To test whether activity of bone morphogenetic proteins (BMPs) might be regulated by using cytokines, we developed a study model to examine the influence of cytokines on BMP activity in human bone. During the course of this study, we examined the following, i. e. ; 1. possibility of regulation of BMP activity by additional cytokines, 2. possibility of human bone formation in an experimental animal, 3. possibility of normal bone formation in the experimental animal, and 4. possibility of bone formation induced by BMP on the human bone tissue in the experimental animal. From these examinations, the following were clarified, i. e. 1. BMP activity can be influenced by additional cytokines, 2. human bone formation in C.B-17/Icr-scid/scid (C.B-17 scid) mice can be observed at least four months after the human bone transplantation, 3. normal bone formation can be observed in the C.B-17 scid mice when compared with the bone formation in their normal control mice, and 4. on the transplanted human bone in the C.B-17 scid mice, newly formed bone induced by BMP injection can be observed. In conclusion, the C.B-17 scid mice with transplanted human bone may be a potential tool for analysis of the influence of cytokines on BMP activity in human bone.