INVESTIGATION OF HUMAN BRAIN FUNCTION USING MICRO-SQUID.

利用最小、质量最高的超导量子干涉器件（micro-SQUID）研制了一种新型多通道梯度仪系统。传感器线圈和皮肤之间非常小的距离（3.80毫米）提供了相当高的空间分辨率。由于这是新开发的机器，一开始我们需要解决很多硬件、软件、磁屏蔽室等方面的小问题。最后，花了大约两年半的时间解决了所有问题。然后我们从1999年开始实验。第一项关于周围神经功能的研究发表在1999年的《神经科学通讯》上。应用微型squid成功地记录了人腕部正中神经在数字神经刺激后的感觉神经动作场（NAF）的实际全像。NAF显示了12个通道的双相波形，等磁场图清晰地显示了移动的四极模式。四极子由一个去极化的偶极子和另一个复极化方向相反的偶极子组成。重建磁场图得到的神经极化长度约为17 cm，磁场复合物以58.7 m/s的速度沿神经从腕部远端向近端移动。

We developed a new multi (twelve) - channel gradiometer system with the smallest and highest quality superconducting quantum interference device (micro-SQUID). A very small distance (3.80 mm) between the sensor coils and the skin provides quite high spatial resolution. Since this was the newly-developed machine, at first, we had to solve many small problems in terms of hardware, software, and magnetic shielded room. Finally, it took approximately 2 and a half years to solve all problems. Then we started the experiments from 1999.The first study was published in Neurosciecne Letters in 1999 concerniong peripheral nerve function. The actual whole image of the sensory nerve action fields (NAF) of the human median nerve at the wrist were successfully recorded following digital nerve stimulation by using the micro-SQUID.The NAF showed the biphasic waveform at each of the 12 channels, and the isomagnetic field map clearly showed the moving quadrupole pattern. The quadrupole comprised a dipole for depolarization followed by another dipole with the opposite direction for repolarization. The polarized length of the nerve obtained by reconstructing the magnetic field maps was approximately 17 cm, and the magnetic field complex moved along the nerve from the distal to the proximal part of the wrist at 58.7 m/s.