Novel Methods for Herbicides Analysis Using Biomimetic Materials

本研究利用分子印迹合成的人工受体作为固相萃取分离介质，开发了一种新的目标农药分析体系。1997-1998年开发了一个用于分子印迹聚合物合成和评价的自动化系统，结果表明，组合方法适合于分子印迹聚合物合成中反应条件的优化和功能单体的选择。在1999-2000年间，尝试了对真实样本的改编。考察了亲和固相萃取法测定河水和土壤中阿特拉津残留量的方法，建立了一种可靠的方法。以阿特拉津为模板分子，在固相萃取过程中，难于去除的阿特拉津在固相萃取过程中泄漏，影响了分析结果。通过在制备阶段使用虚拟模板分子代替阿特拉津，如烷基三聚氰胺衍生物，克服了这一问题。

In this study, artificial receptors synthesized by molecular imprinting were applied as separation media for solid phase extraction to develop new analytical systems for target agricultural chemicals. An automated system for molecularly imprinted polymer synthesis and evaluation was developed in 1997-1998, and it appeared that a combinatorial approach was suitable for the optimization of reaction conditions and functional monomer selection in molecularly imprinted polymer synthesis. During 1999-2000, the adaptation for the real sample was tried. The procedure of affinity solid phase extraction of atrazine residue in river water and soil was examined, and it was finally established as a reliable method. It became clear that atrazine which could not be removed in the preparation stage leaked out during solid phase extraction when atrazine was used as a template molecules and it affected the results of analysis. This problem was overcome by using dummy template molecule in the preparation stage instead of atrazine such as alkyl melamine derivatives.