Development of the program for analysis of the dynamic behavior of the organ of Corti

耳蜗中的Corti器（OC）将声音转化为听觉神经纤维中的动作电位。由于耳蜗对创伤的极端脆弱性，阻止了可以证实这一过程内在性的实验观察，因此构建了OC的二维有限元模型。由于DC浸没在淋巴液中，在数值分析OC的动态特性和流体压力分布时，必须考虑OC与淋巴液的相互作用。然而，OC的复杂结构以及OC的流体和结构之间的材料性质的巨大差异使使用市售FEN应用的淋巴-OC相互作用的建模复杂化。因此，开发了考虑流体-结构相互作用的原始程序。当流体压力波动由镫骨振动引起时， ...更多信息 压力波在耳蜗中发生。由于OC是由这些压力波驱动的，因此了解它们的频率特性非常重要。然而，由于难以独立测量这些波，因此没有关于这些波的经验观测的报告。使用该模型，预测的大小和相位的快波和慢波，以便拟合的数值获得的压力分布在鼓阶与颅内压力测量。接下来，当这些预测的压力被施加到OC时，OC的动态行为被分析。可以得出以下结论：1.对于整个频率范围，快波的幅度随着频率的增加而增加。慢波的幅度随着频率的增加而逐渐增加，直到在特征频率（CF）处达到最大值，然后急剧福尔斯.枕大孔在基底膜蜗轴侧的端部有旋转运动。少

The organ of Corti (OC) in the cochlea transforms sounds into action potentials in auditory nerve fibers. As the extreme vulnerability to trauma exhibited by the cochlea prevents the experimental observation that could confirm the inherence in this process, the two-dimensional finite-element model of the OC was constructed. Using this model, the dynamic behavior of the OC was analyzed.As the DC is immersed in lymph fluid, the interaction between the OC and the lymph fluid must be taken into account when the dynamic behavior of the OC and fluid pressure distribution are numerically analyzed. However, the complex structure of the OC and the large difference in material properties between the fluid and the structure of the OC complicate modeling of the lymph-OC interaction using commercially available FEN applications. Therefore, the original program was developed to consider the fluid-structure interaction.When a fluid pressure fluctuation is induced by vibration of the stapes, two types … More of pressure waves occur in the cochlea. As the OC is driven by these pressure waves, it is important to understand their frequency characteristics. However, there have been no reports on empirical observations of these waves, because of the difficulty of measuring them independently. Using the model, the magnitude and phase of the fast and slow waves were predicted so as to fit the numerically obtained pressure distribution in the scala tympani with that of the intracochlea pressure measurement. Next, the dynamic behavior of the OC was analyzed when these predicted pressures were applied to the OC. The following conclusions can be drawn:1. The magnitude of the fast wave increases with increasing frequency for the entire frequency range. The magnitude of the slow wave increases gradually with increasing frequency until it reaches a maximum at the characteristic frequency (CF), and it then falls sharply.2. The OC shows a rotational movement around the end of the modiolus side of the basilar membrane. Less