Low-modulus Ti-Nb alloys coated with sputter-deposited hydroxyapatite as biomaterial in bone contact

磷酸钙涂层钛铌合金将作为骨接触的潜在生物材料进行系统的探索。将通过增材制造制备具有不同孔隙率的特定形状的β相Ti-Nb合金样品。将根据杨氏模量与皮质骨杨氏模量匹配的标准，对10-27原子%范围内的Nb含量进行优化。与骨接触的生物活性作用的增强将通过Sr-或Mg-掺杂的羟基磷灰石（磷酸钙）的RF-磁控溅射沉积来实现。预期样品的表面化学和形貌可调节细胞粘附、增殖和生长，以获得更好的骨附着。将通过体外细胞培养研究该涂层材料，以得出材料参数的影响，即金属基材和磷酸钙涂层的组成。目标是为骨接触的这些金属材料设置参数，基于具有磷酸钙涂层的弹性Ti-Nb合金（也是多孔），以促进骨生长。因此，将获得对新型Ti-Nb合金与生物活性磷酸钙涂层结合应用于骨接触的基本见解，为改进植入物（如内假体或牙科植入物）开辟了途径。

Calcium phosphate-coated titanium-niobium alloys will be systematically explored as potential biomaterials in bone contact. Beta-phase Ti-Nb alloy samples in defined shape with different porosities will be prepared by additive manufacturing. The optimization of the Nb content in the range of 10-27 at% will be performed based on the criterion to match the Young modulus to that of cortical bone. The enhancement of a bioactive action in contact with bone will be accomplished by RF-magnetron sputter deposition of Sr- or Mg-doped hydroxyapatite (calcium phosphate). The surface chemistry and topography of the samples is expected to modulate cell adhesion, proliferation and growth for a better bone attachment. This coated material will be studied by in-vitro cell culture to derive the influence of the materials parameters, i.e. the composition of the metallic base material and the calcium phosphate coating. The goal is to have a parameter set for these metallic materials in bone contact, based on elastic Ti-Nb alloys (also porous) with a calcium phosphate coating to promote bone growth. Thus, fundamental insight into the combination of novel Ti-Nb alloys with bioactive calcium phosphate coatings for an application in bone contact will be obtained, opening the pathway for improved implants like endoprostheses or dental implants.