Urologial Diseases in a Aging Society: From Genetic to Medical Csre (UroAgeCare)

高年龄和虚弱的患者的特点是对压力的不适当反应，这导致良性和恶性疾病的不良结局的频率更高。这最终导致对内科或外科治疗的反应可能导致更高水平的死亡率、制度化和残疾的临床情景。与标准患者群体相比，关于这种疾病的遗传、表观遗传学和免疫学背景的信息很少，仍然是一个有争议的问题。值得注意的是，尽管新的外科和医学干预措施在泌尿外科不断发展，但临床试验的选择标准通常会导致低估或排除高年龄或低表现状态的患者。鉴于西方国家的人口发展，随着高龄患者数量的增加和合并症数量的增加，对年龄和虚弱之间的相关性进行更深入的分析是值得的。泌尿科是受日益增长的老年人人口影响最大的医学专业，因为泌尿科问题本质上在老年人中更常见，而65岁及以上患者的护理在泌尿科医生的执业中占很大比例。然而，到目前为止，还没有在研究水平上做出明确的努力，既不是实验的，也不是翻译的，因此当我们在临床环境中照顾老年患者时，我们面临着知识上的可怕的缺陷。为了在这个患者队列中为未来对泌尿系统疾病的更具体的诊断和治疗方法创造基础，更深入的多学科研究评估·与年龄和虚弱相关的泌尿系统疾病的自然历史和生理学·分子生物学、免疫学、新陈代谢和其他与年龄相关的因素中导致内科或外科治疗反应性的复杂变化的细节(即药物遗传学，·与并发疾病的互动及其对各自治疗的影响·在提供生活质量调整治疗信息的方面，对老年和虚弱患者进行评估和干预的健康经济学相关性DFG-Nachwuchsakademie：老龄化社会中的泌尿系统疾病：从遗传学到医疗保健(UroAgeCare)的目标是将来自不同医学领域的临床医生和研究人员的当前尖端知识整合到一个跨专业教员中，在年龄和虚弱的专题下研究泌尿系统疾病和护理的各个方面。考虑到所描述的教职员工的高度专业知识，一组精选的年轻研究人员将能够生成高质量的提案，为个人项目量身定做，同时开拓泌尿外科领域以外的更多领域。

High patient age and frailty are characterized by an inappropriate response to stress, that results in a higher frequency of adverse outcomes in benign and malignant disease. This ultimately leads to clinical scenarios where response to medical or surgical treatment may result in higher levels of mortality, institutionalization and disability. Information on the genetic, epigenetic and immunological background of this condition as compared to a standard patient population is scarce and still a matter of debate. Noteworthy, despite ongoing evolution of novel surgical and medical interventions in urology, selection criteria of clinical trials commonly result in an underestimation or exclusion of patients with high age or low performance status. Given the demographic development in Western countries, with increasing numbers of patients in advanced ages and with a growing number of comorbidities, a more profound analysis of the relevance of age and frailty is worthwhile. Urology represents the medical specialty that is most affected by the growing demographic of older adults as urological problems are by nature more common in elderly people, and care of patients aged 65 and older represents a large proportion of urologists’ practices. However, no explicit efforts on a research level, neither experimental nor translational, have been made till now in urology, so that we face a tremendeous deficite in our knowledge when taking care on elder patients in a clinical setting.To create a base for future more specific diagnostic and therapeutic approaches to urological conditions in this patient cohort, more in depth multidisciplinary research evaluating• the natural history and physiology of urological disease associated with age and frailty• specifics of the complex alterations in molecular biology, immunology, metabolism, and other age dependent factors contributing to responsiveness to medical or surgical treatment (i.e.pharmacogenetics, surgical outcome studies) • interaction with concurrent disease and their implications for the respective treatment• health-economic relevance of assessment and interventions in aged and frail patients under the aspect of providing information on quality-of-life-adjusted treatmentThe objective of the DFG-Nachwuchsakademie: Urological Diseases in an Ageing Society: From Genetics to Medical Care (UroAgeCare) is to integrate current cutting-edge knowledge from clinicians and researchers from diverse medical fields into an inter-professional faculty addressing all aspects of urological disease and care under the specific topic of age and frailty. Given the high expertise of the delineated faculty members, a selected group of young researchers will be able to generate high quality proposals, tailored for the individual project while opening additional reach beyond the field of urology.