Biomechanics of Structure and Function of Living Cells, Tissues, and Organs

从生物力学的角度研究活细胞、组织、器官和人体及其组成部分的结构和功能。为此，该项目由以下五个项目组成：1）活细胞、组织和器官的力学特性; 2）骨科系统的生物力学和运动分析; 3）循环系统的生物力学; 4）计算生物力学; 5）生物组织器官的功能适应和重塑。从这些研究项目来看，首先，我们可以确定各种活细胞、组织和器官的基本生物力学性质，包括：血管内皮细胞、平滑肌细胞、成纤维细胞、弹性蛋白、胶原蛋白、动脉、心脏和骨骼肌、肌腱和韧带、骨骼、心脏和肺。这些数据和以前发表的文章中出现的其他数据被编辑成一本书，题为“活细胞、组织和器官的机械性能数据书”。“此外，内皮细胞、心脏和血管、骨骼以及其他细胞和组织对压力的反应也受到了影响，并具有功能适应和重塑的能力。这些结果在题为“生物力学-功能适应和重塑”的书中进行了阐述。计算方法和技术可以有效地用于肌肉收缩的分子分析、骨重建的生物力学模拟、人工膝关节的生物摩擦力学、局部血流的数值分析等。从这些研究中获得的结果在题为“计算生物力学”的书中进行了阐述。这些书都是用英语写的，由东京的Springer-Verlag出版社出版。

Structure and function of living cells, tissues, organs, and body and its components were studied biomechanically. For this purpose, the project was composed of the following five programs : 1) Mechanical properties of living cells, tissues, and organs ; 2) Biomechanics of orthopaedic systems and motion analysis ; 3) Biomechanics of Circulatory system ; 4) Computational biomechanics ; and 5) Functional adaptation and remodeling of biological tissues and organs.From these research programs, first of all, we could determine basic biomechanical properties of various kinds of living cells, tissues, and oragns, which include : vascular endothelial cells, smooth muscle cells, fibroblasts, elastin, collagen, arteries, heart and skeletal muscle, tendon and ligament, bone, and heart and lung. These data and other data appeared in previously published articles were edited into a book entitled "Data Book on Mechanical Properties of Living Cells, Tissues, and Organs."In addition, it was minifected that endothelial cells, heart and blood vesels, bone, and other cells and tissues respond to stress, and have an ability of funcitonal adaptation and remodeling. These results were publised in the book entitled "Biomechanics - Functional Adaptation and Remodeling". Computational method and technique could be effectively utilized for, for example, molecular analysis of muscular contraction, biomechanical simulation of bone remodeling, biotribomechanics of artificial knee joint, numerical analysis of local blood flow. The results obtained from these studies were publised in the book titled "Computational Biomechanics". These books were all written in English, and published from Springer-Verlag, Tokyo.