The effect of dioxine on allergic rhinitis

虽然环境污染物2,3,7,8-四氯二苯并-对二恶英（TCDD）通过与Ah受体的相互作用在实验动物中是一种极强的致癌物和免疫抑制剂，但其对中性粒细胞功能的可能作用尚未确定。除了对感染性微生物具有重要作用外，中性粒细胞还与抗肿瘤耐药性有关。本研究考察了体外暴露于TCDD对人中性粒细胞的影响。TCDD以剂量依赖性的方式上调中性粒细胞黏附分子的表达。

Although the environmental contaminant 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD), via its interaction with the Ah receptor is an extremely potent carcinogen and immunosuppressive agent in experimental animal, its possible actions on neutrophil function have not been determined. In addition to their importance against infectious microorganisms, neutrophils have been implicated in antitumor resistance. The present study examined the effects of in vitro exposure to TCDD on human neutrophils. TCDD upregulate the expression of adhesion molecule on neutrophils dose dependent manner.