Bioactive Polymers for Wound Healing Applications

VitroGroR是一种促进细胞生长和迁移的生长因子复合物，因此在治疗伤口方面具有很大的潜力。拥有VitroGroR商业化权利的组织疗法公司正在寻求开发将VitroGroR以活性形式输送到伤口环境的方法。本项目将针对这一问题提出两种解决方案；一种生物活性绷带，包含微球和水凝胶基质的新型组合，其次是用于治疗深度伤口的原位可聚合基质。通过在微球内封装和使用抑制mmp的共聚体，生长因子复合物将免受侵袭性蛋白酶的侵害。

VitroGroR is a growth factor complex which enhances cell growth and migration, and hence has great potential for treating wounds. Tissue Therapies, which holds the rights to commercialization of VitroGroR, is seeking to develop methods of delivering VitroGroR in its active form to the wound environment. Two solutions to this problem will be developed in this project; a bioactive bandage containing a novel combination of microspheres and a hydrogel matrix, and secondly an in-situ polymerisable matrix for treatment of deep wounds. The growth factor complex will be protected from aggressive proteases through encapsulation within microspheres, and the use of MMP-inhibiting comonomers.