Polymeric micelle nanocarrier for drug and gene delivery

为了实现对顽固性肿瘤的靶向治疗，我们开发了功能聚合物胶束，结合了对细胞内低pH条件的敏感性和结合特定细胞递送抗肿瘤药物的能力，并在荷瘤小鼠体内研究中证明了其有效性。此外，为了建立基于基因传递的分子癌症治疗，我们开发了一种基于聚合物胶束的非病毒基因载体，该载体在细胞内还原条件下通过交联可切割稳定，并成功应用于抗血管生成癌症治疗。

To realize the targeting therapy against intractable tumors, we developed functional polymeric micelles integrated with the sensitivity to intracellular low pH conditions and the ability to bind the specific cells for the delivery of antitumor agents, and demonstrated their effectiveness in the in vivo study using tumor-bearing mice. Also, to establish the molecular cancer therapy based on gene delivery, we developed a non-viral gene vector based on polymeric micelles stabilized through the cross-linking cleavable under the intracellular reductive conditions, and succeeded in their application to antiangiogenic cancer therapy.