Development of new strategy for detection of disease denes

为了确定常见于疾病等多因素疾病的易感基因，我们开发了两种方法，一种是利用3万颗微卫星进行全基因组关联研究（GWAS），另一种是在无系谱记录的随机交配群体中检测性状与标记之间的连锁关系。利用这些新方法，我们可以鉴定出30多个疾病易感基因。针对基于这些疾病基因的基因组药物发现，我们开发了基于硅网络分析和新的酵母双杂交系统。

In order to identify susceptible gene for multi-factorial disease such as common disease, we have developed two methods, GWAS (genome-wide association study) using 30,000 microsatellites and detection of linkage between a trait and a marker in a random mating population without pedigree record. Utilizing these new methods, we could identify more than 30 disease susceptible genes. Towards genome-based drug discovery based on these disease genes, we have developed in silico network analysis and new yeast two hybrid system.