Synthesis of stimuli-responsive star polymers for controlled drug delivery

该项目旨在通过可控自由基聚合技术制备适用于药物输送的新型星形聚合物。这种星形聚合物可以用来在人体内以受控的方式随着时间的推移释放药物，从而能够靶向特定的部位，即肿瘤。星形聚合物的结构和大小会影响其释药特性，通过可控自由基聚合技术可以很容易地改变星形聚合物的结构和尺寸。与类似结构的胶束相比，这些新型星形药物有望改善药物的释放动力学，因为它们在注射时具有更高的稳定性。

The project aims to prepare novel star polymers suitable for drug delivery via controlled radical polymerization techniques. Such star polymers can be employed to release drugs within the human body in a controlled manner over time and are thus able to target specific sites, i.e. a tumor. The release characterisitics are be influenced by the structure and the size of the star polymer, which can easily be altered via controlled radical polymerization techniques. These novel stars are expected to improve the release kinetics of the drug comparing to similar structured micelles due to their higher stability upon injection.