DEVELOPMENT OF INTRACRANIAL PRESSURE CONTROL SYSTEM

(1)数学模型分析的建立为了使颅内压增高的病人获得最佳的治疗效果，有必要对高渗溶液（如甘露醇或甘油）的各种参数进行分析。从数学上介绍了颅内压（ICP）由血液和脑组织多室组成的响应模型系统。(2)颅内压增高因子的引入通过分析本系统所用甘油给药后颅内压的变化，建立了脑水肿的数学模型。该模型系统中水分迁移的原因是渗透压差，并确定为ICP增加因子V。(3)临床病例的模拟通过对该系统的临床病例模拟，证明了该理论模型对人体颅内压监测的响应非常相似。(4)ICP控制器的研制与应用对ICP控制器进行了进一步的开发。该控制器在临床上实现了ICP的自动控制。最小有效剂量的甘油可以通过为每个患者预设所需的ICP来自动给药。

(1) Construction of Mathematical model analysisIt is necessary to analyse various parameters responding to hypertonic solutions such as mannitol or glycerol, in order to achieve the best therapeutic results for patients having increased intraclanial pressure (ICP). The responding model system for the ICP composing of multi-compartments of blood and brain tissue was mathematically introdused.(2) Introduction of ICP increasing factorBy analysing the change of the ICP under administration of glycerol used in this system, the mathematical model for brain edema was developed. The cause of water transfer in this model system was indicated as the difference of the osmotic pressure and determined as ICP incerasing factor, V.(3) Simulation of clinical caseIt was demonstrated that this theoritical model responded quite similarly to human ICP monitored by simulating this system for clinical cases.(4) Development and Application of ICP controllerThe ICP controller was further developed. The automatic control of ICP was clinically achieved by using this controller. The minimal effective dose of glycerol can be automatically administered by presetting a desirable ICP for each patient.