A developmental biological analysis: Neurotropic effects of estrogen on the perinatal hypothalamic tissue transplanted into the adult rat brain.

将新生雌性大鼠的视前区（POA）或大脑皮层移植到切除卵巢的成年大鼠的第三脑室。从移植当天起，将雌二醇-17装入硅胶管皮下植入宿主动物4周。移植4周后，在光镜和电镜下观察脑皮质移植后POA的变化。经宿主暴露雌激素4周后，POA移植物的体积显著增加。雌激素处理组的树突轴和脊柱突触数量明显高于未处理的POA组。相比之下，对照组和雌激素组之间移植到大脑的结缔组织的体积没有显著差异。结果提示，雌激素对脑室POA移植物神经元基质的发育有刺激作用，增加其体积和突触数量。

The preoptic area (POA) or cerebral cortex taken from newborn female rats was transplanted into the third ventricle of ovariectomized adult rats. From the day of transplantation, estradiol-17 in a Silastic tube was implanted subcutaneously into host animals for 4 weeks. The POA of cerebral cortes transplants were examined at light- and electron-microscopic levels 4 weeks after transplantation.Estrogen exposure for 4 weeks via the host induced a significant increase in the volume of the POA grafts. The number of axodendritic shaft and spine synapses was significantly greater in the grafts exposed to estrogen than that of the POA grafts without estrogen tratment. In contrast, there was no significant difference in the volume of conticat tissues transplanted into the brain between the control and estrogentreated grups.The results suggest that estrogen has a stimulatory effect on the development of neuronal substrates in the ntraventricular POA graft, increasing its volume and synaptic population.