An Integrated Experimental, Preventive and Epidemiological Study on Stress in Modern Society

研究人员原本打算在1989年8月的首次会议上统一压力的概念和定义，并在2日的会议上讨论了研究的主题、计划和方法。和第三个。1989年11月的会议和美联储。然后在1991年2月的最后一次会议上提出了新的方面的结果。在这两年中，研究人员分别进行了研究项目。所提交的报告总结如下：作为基于对工人的实地调查的预防研究，阐明了对压力的主观认识与压力因素(H.青山)、工作生活满意度、生活方式和主要症状(K.Morimoto)、健康实践和空闲时间行为(T.Suzuki)之间的关系。作为对日常生活中应激的研究，道路交通噪声对睡眠的影响被定量地应用于EEG(S.Suzuki)。应激在心血管疾病(H.Tanaka)、消化性溃疡(K.Kawai)和老年住院患者(N.Yamashita)的发生和发展中的作用进行了流行病学调查。实验研究包括光中重复相移的影响。其中包括：S.Sasagawa(S.Sasagawa)，应激与缺镁的关系(Y.Itokawa)，与细胞色素P-450的关系(T.Takano)，活性氧的形成，诱导儿茶酚胺对DNA的损伤(S.Kawanishi)，内源性单胺氧化酶抑制剂、苯二氮卓受体配体(O.Wada)，应激诱导蛋白和血红素加氧酶(R.Tokunaga)，应激下体内微量元素的变化和作用(K.Saito)，金属硫蛋白对应激组织的影响(K.Nishino)，应激诱导金属硫蛋白的定量监测(Y.Kojima)。研究结果表明，系统研究是促进现代社会压力澄清的有效途径。

The investigators had intended to unify the concept and definition of stress at the initial meeting in Aug. 1989, and discussed themes, plans and methods of research at the 2nd. and 3rd. meeting in Nov. 1989 and Fed. 1990 respectively, and then presented the results with new aspects at the final meeting in Feb. 1991. During these 2 years the investigators proceeded with the research programs individually. The presented reports were summarized as follows :As preventive studies based on field surveys for workers, relationships between subjective recognition of stress and stress factors (H. Aoyama), satisfaction of working-life, lifestyle and primary symptoms (K. Morimoto), health practices and behaviors in free time (T. Suzuki) were clarified. Effect of road traffic noise on sleep was evaluated on EEG quantitatively (S. Suzuki) as a study of stress in usual life.The roles of stress in onset and progress of cardiovascular disease (H. Tanaka), of peptic ulcer (K. Kawai), and in geriatric hospitalizeds patient (N. Yamashita) were investigated epidemiologically.The experimental researches included that effects of repeated phase shifts in light. and dark on lipid metabolism (S. Sasagawa), relationships between stress and magnesium deficiency (Y. Itokawa), and cytochrome P-450 (T. Takano), and active oxygen formation, DNA damage by induced catecholamines (S. Kawanishi), and involvement of endogenous monoamine oxidase inhibitors, benzodiazepine receptor ligands (O. Wada), stress-induced protein and hemeoxygenase (R. Tokunaga), the changes and roles of trace elements in body under stress (K. Saito), effects of metallothionein on stressed tissues (K. Nishino), quantitative monitoring by stress-induced metallothionein (Y. Kojima) were clarified.From these results, it was suggested that systematic research was effective to advance the clarification of stress in modern society.