Synthesis of the pyrrolo[2,1-c][1,4]benzodiazepines: potent DNA binders

与DNA结合的化学物质作为抗癌药物有着悠久的历史。近年来，生物技术革命极大地扩展了我们对这些药物如何起作用以及广泛的其他疾病的遗传基础的理解。该项目的目的是发现选择性结合DNA的新型化合物。从一类天然存在的化合物（称为吡咯并苯并二氮杂卓）作为模板开始，它将开发强大的新方法，以提供全新的DNA相互作用分子，这些分子具有治疗癌症或其他遗传疾病的新药的巨大潜力。

Chemicals that bind to DNA have a long history of use as anticancer drugs. In recent times, the biotechnology revolution has greatly expanded our understanding of how these drugs work and the genetic basis of a wide range of other diseases. The aim of this project is to discover novel compounds that selectively bind to DNA. Starting from a class of naturally occurring compounds (called the pyrrolobenzodiazepines) as a template, it will develop powerful new methods to supply wholly new DNA interactive molecules with great potential as new drugs to treat cancer or other genetic diseases.