Studies on Protective Effects of Breast Feeding Against Rotavirus Infection in Infants.

采用ELISA法检测产妇血清（N=194）和脐带血清（N=291）中人轮状病毒（HRV， wa -株）特异性IgG抗体和初乳（K=304）中人轮状病毒（HRV， wa -株）特异性IgA抗体，探讨母乳喂养对婴儿腹泻的保护作用。通过调查婴幼儿腹泻史和母乳喂养时间，对婴幼儿“冬季胃肠炎”的发病率进行调查。结果总结如下：HRY抗体水平按宇称。HRY抗体在母体血清和初乳中的阳性率几乎相似。分别为93.0%和91.3%。初产妇血清抗体水平分布在滴度为20 GEU时达到峰值，而初产妇在滴度为60 GEU时达到峰值。更高的滴度。多产妇的初乳比初产妇的初乳含量高。二胎和多胎小鼠的胎血清、脐带血清和初乳中HRY抗体的平均水平显著高于第一胎。产后2年内产妇血清和初产妇乳中hrv特异性免疫球蛋白类的平均水平明显高于初产妇。然而，分娩间隔4年及以上的多产妇女的平均抗体水平与初产妇女相似。这些结果表明，母亲的HRY抗体可能因其子女再次感染IIRV而增加。婴儿“冬季胃肠炎”的发病率。母乳喂养和配方奶喂养的婴儿比例分别为36%和8%。56%的婴儿接受混合喂养。1588例患儿中，冬季胃肠炎224例（14.4%）。1岁前单独或混合配方奶喂养的婴儿冬季胃肠炎发病率明显高于长时间（6个月以上）母乳喂养的婴儿。大多数母亲的初乳中含有抗轮状病毒抗体，这些抗体通过母乳喂养转移给婴儿。目前的研究结果表明，长时间母乳喂养（超过6个月）对婴儿HRY感染是有效的。少

Human rotavirus(HRV, Wa-strain)specific IgG antibodies in maternal(N=194)and cord serum(N=291)and HRV specific IgA antibodies in colostrum(K=304)were measured by ELISA to elucidate the protective effect of breast-feeding against diarrhea in infants. And we studied the morbidity of "winter gastroenteritis" in infants using the questionnaires on the infant's history of diarrhea and the period of breast feeding. The results were summarized as follows :Levels of HRY antibodies by parity.Positive rates of HRY antibodies in maternal serum and colostrum were almost similar. 93.0% and 91.3% respectively. The distribution of antibody levels in maternal sera of primiparas showed the peak at 20 GEU of titer, while the peak was seen at 60 GEU for mdltiparas. Higher titer. . Levels were also observed in colostra of multiparas than those of primiparas. Mean levels of antibodies to HRY in niaternal and cord sera and colostra of second-paras and multiparas were significantly higher than those of primi … More paras.Mean levels of HRV-specific-immunoglobulin classes were significantly higher in maternal sera and colostra of multiparas within 2 years after delivery than those of primiparas. However, mean levels of antibodies of multiparas with 4 years and more interval of delivery were similar to those of primiparas. These results suggest that mother's HRY antibodies might be increased by re-infection with IIRV from their children.Incidence rates of "winter gastroenteritis" in infants.Percentages of the infants fed with breast-milk and formula-milk were 36 % and 8 I, respectively. Fifty-six percent of the infants received mixed feeding. Of the 1588 infants, 224(14.4%)were affected with winter gastroenteritis. The morbidity of "winter gastroenteritis" before I year old in infants received with formula-milk alone or mixed feeding were significantly higher than that of infants with long period(over 6 months)breast-feeding.Most of mothers possessed antirotaviral antibodies in their colostra which were transferred to their infants by breast feeding. The present findings suggested that long period breast-feeding(over 6 months)was effective against HRY infection in infants. Less