Studies of Experimental Oral Tumors Produced by Heterocyclic Amines in the Broiled Food

近年来，从氨基酸和熟食的热解产物中分离出了许多诱变化合物。这些诱变剂是芳香杂环胺，其中有5种是Trp-P-2、Glu-P-1、MeIQ、MeIQx和IQ。在这个项目中，进行了四个实验。第一个实验用Trp-P-2或Glu-P-1对仓鼠舌头处理16周，然后对其进行损伤处理。这些舌未显示任何明显的上皮发育不良。在第2次实验中，经Trp-P-2或MeIQ处理4周并双伤的仓鼠舌部大部分出现上皮发育不良。在第三个实验中，用Trp-P-2或MelQx或IQ联合双伤处理4周的仓鼠舌头，经常出现上皮发育不良。实验四，大鼠牙龈创面应用Glu-P-1后，上皮-结缔组织连接处，尤其是基底层超微结构发生明显改变。

Recently, many mutagenic compounds have been isolated from pyrolysates of amino acids and cooked foods. These mutagens are aromatic heterocyclic amines, and Trp-P-2, Glu-P-1, MeIQ, MeIQx and IQ are five of them. In this project, four experiments were performed. In the first experiment, the tongues of the hamsters were treated with Trp-P-2 or Glu-P-1 for 16 weeks, and then the tongues were wounded. These tongues did not show any marked epithelial dysplasias. In the second experiment, most of the tongues of the hamsters which were treated with Trp-P-2 or MeIQ for 4 weeks together with double woundings, showed epithelial dysplasias. In the third experiment, the tongues of the hamsters which were treated with Trp-P-2 or MelQx or IQ for 4 weeks in combination with double woundings, frequently showed epithelial dysplasias. In the forth experiment, the application of Glu-P-1 to the gingival wound in rats induced the marked ultrastructural changes in the epithelium-connective tissue junction, particularly the basal lamina.