Studies on the dynamics of ultra-trace elements in the body

本研究从分析和生物化学两个方面对超痕量元素在人体内的分布和功能作用进行了研究，取得了以下研究成果：1）建立了ICP-MS法同时测定生物样品中超痕量元素的方法。（2）测定了人脑5个脑区的超微量元素和微量元素。年龄与K、Rb呈显著负相关，与Cd、Sn呈显著正相关，分布于人脑大部分区域。Rb的浓度显着下降，衰老也观察到在7个地区的大鼠脑。（3）测定胃癌患者癌组织中超微量和微量元素的含量。胃癌组织中Cd和Sr浓度显著降低，Cu和Ti浓度显著升高。 ...更多信息 非癌性胃组织4)本实验测定了不同时间束缚应激和解除束缚应激后大鼠脑内7个脑区Cu、Zu、Mn、Mo含量及海马Zn释放的变化，其中3个脑区的Cu、Zu含量在束缚应激后下降，解除束缚应激后2 h仍未恢复到对照水平。锰和钼浓度下降，这取决于约束应力的持续时间，并恢复到控制水平后2小时从约束应力释放。短期束缚应激可引起海马组织锌的释放。5）测定了染矽尘大鼠血浆和脏器中超微量和微量元素的含量。暴露于硅尘后，血浆和肺中的铜浓度增加，这取决于剂量和时间。暴露于矽尘后，血浆和肺中的锌浓度均降低。结果提示，Cu可作为矽尘对大鼠和/或人肺损伤的一个有希望、准确和敏感的指标。血浆锌水平可作为肺损伤的辅助指标。少

In the present study, we intended to evaluate the distributions and functional roles of ultra-trace elements in the body from analytical and biochemical investigations.Results obtained in the present investigations are as follows ; 1)We established the simultaneous multi-analytical procedure to determine the ultra-trace elements by ICP-MS spectrometry in biological samples. 2)Ultra-trace and trace elements were measured in 5 regions of human brains. Significant negative correlations between age and K or Rb and significant positive correlations between age and Cd or Sn were found in most regions of the human brain. Significant decreases in Rb concentrations by aging were also observed in 7 regions of the rat brain. 3)Ultra-trace and trace elements concentrations were determined in cancerous tissues in patients with stomach cancer. Significant decreases in Cd and Sr concentrations and increases in Cu and Ti concentrations were observed in cancerous stomach tissues as compared to those in … More noncancerous stomach tissues. 4)Changes in Cu, Zu, Mn and Mo concentrations in 7 regions of the rat brain and release of Zn from the rat hippocampus were determined after various durations of restraint stress and after release from restraint stress.Cu and Zu concentrations decreased in 3 regions by restraint stress and did not return to the controllevels 2 hour after release from restraint stress. Mn and Mo concentrations decreased depending on the duration of the restrain stress and returned to the control levels 2 hour after release from restraint stress. Zn was released from hippocampus tissues by short periods of restraint stress. 5)Ultra-trace and trace elements in plasma and the organs were determined in rats exposed silica dust. Cu concentrations in plasma and in the lung increased depending on dose and time after exposure to silica dust. Zn concentrations both in plasma and in the lung decreased after exposure to silica dust. These results suggest that Cu may be a promising, accurate and sensitive index of lung injury in silicoticrats and/or in human exposed to silica dust in the workplace. The plasma Zn level may serve as a supplementary index of lung damage. Less