Development of measurement system for basilar membrane vibrations using a laser Doppler vibrometer coupled to a microscope.

当我们低声说话时，鼓膜振动的幅度虽然只有几纳米，但我们可以清楚地理解他们所说的话。据推测，这可能是由耳蜗放大引起的。耳声发射(OAEs)被认为是这种耳蜗术的副产品。然而，这种扩增在耳蜗中的作用机制尚不清楚。因此，本文利用激光多普勒振动仪与复合显微镜相结合的方法，对活体、死亡、缺氧和耳声发射时豚鼠耳蜗基底膜的振动进行了研究，试图阐明耳蜗声发射放大的机制及其在耳声发射产生中的作用。根据活体、死亡和低氧条件下的基底膜振动的测量结果，推测活体豚鼠体内存在耳蜗放大值，并具有非线性，并受适度低氧的影响。此外，对基底膜振动和耳声发射的同步测量表明，耳蜗非线性放大有助于耳声发射的起源。

Although amplitude of tympanic membranc vibrations is only a few nanometer when we talk in a low voice, we can understand clearly what they say. This is speculated to be caused by cochlear amplification. Otoacoustic Emissions (OAEs) are recognized as the byproduct of this cochlear amplication. However, mechanism of the amplification in the cochlea is obscure. Therefore, in this paper, cochlear basilar membrane vibrations of guinea pigs in live, dead, hypoxia conditions and when OAEs are generated using a laser Doppler vibrometer coupled to a compound microscope, and an attempt is made to clarify the mechanism of the cochlear amplification and its contribution toward the generation of OAEs. As the results of the measurements of basilar membrane vibrations in live, dead and hypoxia conditions, it is guessed that cochlear amplifier exists in the live guinea pigs and has nonlinearity and is influenced by the moderated hypoxia. Furthermore, simultaneous measurements of basilar membrane vibrations and OAEs suggest that cochlear nonlincar amplification contributes toward the origin of OAEs.