Basical and clinical study on the bioabsorbable medical devices

使用合成的生物可吸收材料、胶原蛋白及其复合物进行生物可吸收外科器械的开发。结果如下：（1）利用碱溶性胶原蛋白制备了棉状纤维状的新型hemostar材料。通过与传统胶原止血剂的比较，评价止血效果。这表明它具有临床应用的潜力。(2)以明胶、聚谷氨酸和水溶性明胶为原料合成了一种新型生物粘合剂。用犬脾出血模型检测了其粘附效果，显示了其良好的应用前景。(3)复合膜由人羊膜和PGA网（三明治型）制成。在动物实验中，它们被用于人工心包、伤口敷料和缝合加固。他们的评估结果在东京举行的第32届日本人工器官年会上报告。(4)神经连接管由生物可吸收明胶管制成。将猫坐骨神经25 cm长的断端连接起来，植入神经内3个月后，观察其形态学再生和功能恢复情况，并继续将聚-L-乳酸（P-L-LA）制成的生物可吸收支架用于胸部畸形的临床应用，其结果已在Journal of Thoracic Cardiovascular Surgery上报道。

Development of bioabsorbable surgical devices are carried out using synthetic bioabsorbable materials, collagens and their composite. Following are the results ;(1) New hemostar material in the cotton-like fibrous shape are manufactured by alkali-polubilized collagen. Hemostatic efficacies are evaluated in comparison with conventional collagen hemostat. This suggests that it has potential for clinical use.(2) Novel synthesized biological adhesive was prepared from gelatin, polyglutamic acid and water-solubute carbodimide. Adhesive efficacy was tested using bleeding model of the spleens of dogs, indicating its promising future.(3) Composite membrane was developed from human amnions and PGA mesh (sandwich type). They were applied for artificial pericardium, wound dressing and suture reinforcement, in animal experiments. Their evaluated results were reported at the 32nd annual congress on Japanese Artificial Organs held in Tokyo.(4) Nerve connective tube was fabricated from bioabsorbable gelatin tube. 25 cm gabs of the isciadic nerve of cats were connected.Not only morphological regeneration but also functional recovery were determined at 3 months after implantation in the nerve.The clinical application of bioabsorbable struts for chest deformities made from poly-L-lactide (P-L-LA) are continued and their result is reported on Journal of Thoracic Cardiovascular Surgery.