Studies on demyelinating disease in the Eastern Europeans

这个项目是基于我们之前25年的调查结果，调查结果表明，与美国和西欧国家尸检病例中经常观察到的大脑、视神经和脊髓弥散性斑块脱髓鞘疾病不同，日本和中国病例的视神经和脊髓是选择性和严重损伤的。同心圆硬化（Balo病）的典型组织学特征仅见于中国人。根据这一发现，我们仔细检查了在匈牙利、波兰、捷克和罗马尼亚等东欧国家的一些主要大学和医院解剖的脱髓鞘疾病病例。在匈牙利，我们参观了舍克斯费赫尔瓦尔、卡波什瓦尔、医科大学。胸大肌,Med.Univ.Buda。, Nat.lnst.f.N。医学大学米什科尔茨医院精神科博士德布勒森，共调查了145例尸检病例。至少在5例中，弥散性脱髓鞘斑块的西方类型和同心硬化样病变组织学共存。在波兰，我们参观了波兰科学院、华沙医学院、纳特心理研究所等四所研究所。&神经疾病，波兹南医学院，并观察了40例尸检病例。也有少数病例同时观察到弥散性斑块和同心硬化样病变。上述病例的标本仍在检验中，最终结果将在稍后公布。然而，目前已经发现，在中欧混血的东欧国家中，有一组脱髓鞘疾病，其组织学上是中国型同心硬化症与西方型多发性硬化症并存。在全球范围内，这种疾病的病变模式似乎与基因有着非常密切的关系。

This project was based on the result of our previous survey over a 25-year period, which had clarified that, as opposed to the demyelinating disease with disseminated plaques of the cerebrum, optic nerve and spinal cord frequently observed in the autopsy cases in the U.S.A.and Western European countries, the optic nerve and spinal cord are selectively and severely damaged in the Japanese and Chinese cases, and a typical histology of concentric sclerosis (Balo disease) is observed only in the Chinese ones.Based on the finding, we scrutinized cases with demyelinating disease autopsied in some main universities and hospitals in certain Eastern European countries such as Hungary, Poland, Czecho and Romania.In Hungary, we visited Szekesfehervar, Kaposvar, Med.Univ.Pecs, Med.Univ.Buda., Nat.lnst.f.N.& Mental D., Miskolc Hospital, Med.Univ.Debrecen, and investigated 145 autopsy cases in total. At least in five cases, disseminated demyelinating plaques of the Western type and the histology of concentric sclerosis-like lesions coexisited.In Poland, we visited four institutes such as Polish Acad. Science, Warsaw Sch.of Med., Nat.Inst.of Psych.&Nervous disease, Poznan Sch.of Med., and observed 40 autopsy cases. There were also a few cases in which disseminated plaques and concentric sclerosis-like lesions were simultaneously observed.Specimens of the above-mentioned cases are still under examination, and the final result will be reported later. However, it has so far become evident that there is a group of the demyelinating disease in which the histology of the Chinese type of concentric sclerosis coexists with that of the Western type of multiple sclerosis in the cases of Eastern European countries where the Chinese and Europeans were racially mixed.On a global scale, the lesional pattern of the disease seems to be formed in very close relation to genes.