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An immunohistochemical study on nuclear bodies in neurodegenerativediseases with abnormal protein aggregates

An immunohistochemical study on nuclear bodies in neurodegenerativediseases with abnormal protein aggregates
异常蛋白质聚集的神经退行性疾病核体的免疫组织化学研究
批准号：
23659184
负责人：
TAKAHASHI Hitoshi
金额：
$1.83万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659184/
关键词：
脳神経神経変性疾患多系統萎縮症筋萎縮性側索硬化症細胞内凝集体核内小体新経変性疾患

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中文摘要
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英文摘要
The kinetics of two nuclear bodies, PML and Cajal bodies, werestudied in multiple system atrophy (MSA) and sporadic amyotrophic lateral sclerosis (ALS),respectively. In MSA, in the nuclei of the pontine nuclei neurons, PML bodies were found tobe deformed in the presence of r-synuclein-positive intranuclear inclusions: the roundstructures changed to rod-like or linear abnormal ones. Statistically, the entire volume ofPML bodies was significantly decreased in MSA group (n=5) than in control group (n=5). InALS, in the nuclei of the lumbar anterior horn cells, the number of Cajal bodies was significantly decreased in ALS group (n=5: 8.06+/-4.41) than in control group (n=5:17.19+/-4.09). It is tempting to speculate that in MSA and ALS, these decreases of PML andCajal bodies, which are associated with neuronal viability, play an important role inneuronal cell death in relation to abnormalities of r-synuclein and TDP-43, respectively.
期刊论文(28)
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会议论文
Coexistence of Huntington's disease and amyotrophic lateral sclerosis: a clinicopathologic study.
DOI： 10.1007/s00401-012-1005-5
发表时间： 2012-11
期刊： Acta neuropathologica
影响因子： 12.7
作者： [Tada M, Coon EA, Osmand AP, Kirby PA, Martin W, Wieler M, Shiga A, Shirasaki H, Tada M, Makifuchi T, Yamada M, Kakita A, Nishizawa M, Takahashi H, Paulson HL]
通讯作者： Paulson HL
Co-occurrence of argyrophilic grain disease in sporadic amyotrophic lateral sclerosis
散发性肌萎缩侧索硬化症并发嗜银颗粒病
DOI： 10.1111/j.1365-2990.2011.01175.x
发表时间： 2012
期刊： Neuropathology
影响因子： 2.3
作者： [Soma K, Fu YJ, Wakabayashi K, Onodera O, Kakita A, Takahashi H]
通讯作者： Takahashi H
Alterarion of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS.
POLDIP3 剪接的改变与 ALS 影响的组织中 TDP-43 功能的丧失相关。
DOI： --
发表时间： 2012
期刊： PLoS One
影响因子： 3.7
作者： [Odagiri S, Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K., Mori F, Shiga A]
通讯作者： Shiga A
Survival motor neuron (SMN) protein in the spinal anterior horn cells of patients with sporadic amyotrophic lateral sclerosis
散发性肌萎缩侧索硬化症患者脊髓前角细胞中的运动神经元（SMN）存活蛋白
DOI： 10.1016/j.brainres.2010.11.070
发表时间： 2011
期刊： Brain Research
影响因子： 2.9
作者： [Piao Y, Hashimoto T, Takahama S, Kakita A, Komori T, Morita T, Takahashi H, Mizutani, T, Oyanagi K]
通讯作者： Oyanagi K
共 20 条
    Heterogeneity of TDP-43 pathology and clinicopathologic correlations in sporadic amyotrophic lateral sclerosis
    • 批准号：
      26640029
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.16万
    • 财政年份：
      2014
    • 负责人：
      TAKAHASHI Hitoshi
    • 依托单位：
      Niigata University
    Migrants and their 'homes': strategies of non-assimilative adaptations and representations of transnational ties
    • 批准号：
      24310178
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $11.65万
    • 财政年份：
      2012
    • 负责人：
      TAKAHASHI Hitoshi
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      The University of Tokyo
    Relationship between elementary school students' identities on mathematics and construction of mathematical knowledge in elementary mathematics classrooms
    • 批准号：
      24501045
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.16万
    • 财政年份：
      2012
    • 负责人：
      TAKAHASHI Hitoshi
    • 依托单位：
      Joetsu University of Education
    Development of Large-Current Indirectly CooledRadiation-Resistant Magnets
    海外基金