Design of Biodegradable Adhesion Prevention

组织粘连预防材料的研制在外科手术中期待已久。手术后的组织粘连偶尔会导致严重的并发症。已经进行了各种研究来开发防止组织粘连的材料。这些组织起到了屏障的作用，使创伤组织在愈合过程中与邻近组织分离。这些材料应该没有细胞粘连，应该足够灵活和坚韧，以提供对创伤软组织的紧密覆盖，并且在受伤组织完全再生后应该是可生物降解和可吸收的。为了充分实现这些要求，纤维蛋白或多糖等天然聚合物被认为是最适合作为基础材料的，它们作为填充组织间隙的高度吸水性生物材料存在。携带亲水性成分的合成多肽及其共聚物为酶可降解医用…提供了可能性此外，我们还制备了多种类型的亲水性多肽膜，这些多肽膜由亲水性和疏水性氨基酸组成，作为天然纤维蛋白的模型。它们包括：以亲水性多肽为A组分、以聚异戊二烯为B组分的A-B-A型嵌段共聚物、共聚(N-羟基烷基-D，L-谷氨酸)S、由N-羟基烷基-L-谷氨酰胺和L-丙氨酸组成的两组分无规共聚肽、L-亮氨酸或L-缬氨酸，以及由N-羟基烷基-L-谷氨酰胺、L-谷氨酸和L-赖氨酸组成的三组分无规共聚肽。通过在起始膜上与二胺进行交联反应，制备了亲水膜或水凝胶。通常情况下，有效交联度与反应混合物中二胺的摩尔分数成正比。研究了它们在水中的溶胀度、拉伸性能以及在伪胞外液(PECF)中的酶降解行为与本体结构之间的关系。亲水性膜的拉伸性能高度依赖于PECF中的溶胀比和分子链中的疏水部分，其行为是典型的弹性体。这些膜的生物降解表明，降解是整体进行的，而不是在表面上进行的，降解速度还高度依赖于膜的溶胀率、样品侧链的疏水性、有效电荷密度以及D，L共聚单体组成。较少

The development of tissue adhesion prevention material has been long awaited in surgery. Tissue adhesion after surgery occasionally causes serious complications. Various studies have been undertaken to develop materials that prevent tissue adhesion. These function as a barrier to enable traumatized tissue to be separated from adjacent tissues during the healing process. These materials should be free from cellular adhesion, should be flexible and tough enough to provide for a tight cover over the traumatized soft tissues, and should be biodegradable and resorbable after the injured tissue is completely regenerated. To fully realize these requirements, natural polymers such as fiberous proteins or polysaccharides, which exist as highly water-adsorbable biomaterials filling interstices of tissues, have been considered to be best suited as basic materials. Synthetic polypeptides and their copolymers which carry hydrophilic components offer potential for enzymatic degradable medical applic … More ations.We have prepared many types of hydrophilic polypeptide membranes which are composed of hydrophilic and hydrophobic amino acid components as models of natural fibrous proteins. These includes ; A-B-A type block copolymers consisting of a hydrophilic polypeptide as the A component and polyisoprene as the B component, copoly (N-hydroxyalkyl-D,L-glutamaine)s, two-component random copolypeptides consisting of N-hydroxyalkyl-L-glutamine and L-alanine, L-leucine, or L-valine, and three-component random copolypeptides consisting of N-hydroxyalkyl-L-glutamine, L-glutamic acid, and L-lysine. Hydrophilic membranes or hydrogels were prepared by using a crosslinking reaction with diamine on the starting membranes. It was commonly shown that the effective crosslink density was proportional to the molar % of diamine in the reaction mixture. The relation between their bulk structure and properties was investigated with regard to the swelling ratio in water, tensile properties, and enzymatic degradation behavior in a pseudo-extracellular fluid (PECF). The tensile properties of the hydrophilic membranes were highly dependent on the swelling ratio in PECF,and on the hydrophobic portions in molecular chains, whose behavior was typical of an elastomer. Biodegradations of these membranes in viro by a protease indicated that the degradation took place in bulk rather than on a surface, and that the rate of degradation was also highly dependent on the swelling ratio of membranes, the hydrophobicity, effective charge density, as well as D,L-comonomer composition, of the side chains of samples. Less