Influences of exclusion of pulmonary circulation on systemic circulatory conditions

脉搏性动脉血流（PAF），在各种血管活性物质中的代谢作用是一个重要的作用，在体内动脉旁路（VAB）期间减少，包括心血管旁路和ECMO。在一系列慢性动物实验中，VAB中减少的PAF的影响。一个带有两个脉冲式垂直辅助设备（VADs）的双向旁路系统是第一个安装在成人山羊上的。在两周后， VAB将使用正确的上行和左返回Cannels和VAD，并与在返回Cannels中插入的紧凑人工Lung进行组合。PAF将全系统血液流动从100%减少到50、25、10和0%，用一个气球电容器封闭的脉冲式电池。动物的呼吸在任何时候都被充分地保留在土著和人工语言的实验中。111（]SY.+-的平均空气压力和系统性血管阻力减少了。（12至62）SY.+- [）6 mmHg，从1089（]SY.+-。（95至650）（Y.+-）[）150达因·秒·厘米-5，相应地，在PAf中减少100 - 0%。前列腺素E2集中增加了2.1（）SY.+-。[1] 1.6至12.5 [1]SY.+-。[）2.1 pg/dl在PAF中降解至100 - 0%。对PAF的这种可能性变化也适用于等离子体肾上腺素活动和血管紧张素I和II。在对比、肾上腺素和北肾上腺素集中（60（）SY.+-。（28和307）（S.+）[）194皮克/分升，相当于100%的PAF）即使在10%的PAF （49（]SY.+-）也没有改变。[34和217]（S.+-）[）141皮克/分升），但实际上高于442（]SY.+-。（285和628）（S.+-）[519 pg/dl当PAF完全关闭时这种类似的变化模式也被认为是用于抗生素荷尔蒙。在整合中，在VAB衍生物中的降解在比例性标记中对血动力学的显著影响，以及在多样性标记中的挥发性人道主义因素。

The pulmonary arterial blood flow (PAF), which plays an important role in metabolizing various vesoactive substances, is reduced during venoarterial bypass (VAB) including cardiopulmonary bypass and ECMO.The influence of reduced PAF during VAB on hemodynamic and humoral conditions ws investigated in a series of chronic animal experiments. A biventricular bypass system with two pulsatile ventricular assist devices (VADs) was first installed in adult goats. After two weeks of convalescent period, VAB was conducted using the right uptake and left-return cannular and a VAD,in combination with a compact artificial lung interposed in the return cannula. The PAF was reduced stepwise from 100% to 50,25,10, and 0% of total systemic blood flow by occluding the pulmonary artery with a baloon catheter. The animals' respiration was sufficiently maintained with the native and artificial lungs at any time of the experiments. The mean aortic pressure and the systemic vascular resistance decreased from 111(]SY.+-。[)12 to 62(]SY.+-。[)6 mmHg, and from 1089(]SY.+-。[)95 to 650(]SY.+-。[)150 dyne・sec・cm-5, respectively, in proportion to the decrease in PAf from 100 to 0%. The prostaglandin E2 concentration increased from 2.1(]SY.+-。[)1.6 to 12.5(]SY.+-。[)2.1 pg/dl in proportion to the decrease in PAF from 100 to 0%. Such proportional change to the PAF was also observed for plasma renin activity and angiotensin I and II.In contrast, the epinephrine and norepinephrine concentrations (60(]SY.+-。[)28 and 307(]SY.+-。[)194 pg/dl, respectively, at 100% of PAF) did not change appreciably even at 10% of PAF (49(]SY.+-。[)34 and 217(]SY.+-。[)141 pg/dl), but drastically elevated to 442(]SY.+-。[)285 and 628(]SY.+-。[)519 pg/dl when the PAF was completely shut off. The similar mode of change was also noted for antidiuretic hormone. In conclusion, the decrease in PAF during VAB exerts dignificant influences on hemodynamics in a proportional manner, and on vasoactive humoral factors in diverse manners.