The effect of methylation and phosphorylation on ribosome function

该项目旨在发现细胞如何通过修改其核糖体蛋白来调节核糖体的功能和选择性。这会影响蛋白质合成，而蛋白质合成是所有生物生长的核心过程。预期成果包括关于蛋白质合成调控的新知识，改进这一过程的研究技术以及加强国际合作的能力。人工调控核糖体的新途径也可能出现，与合成生物学和工业酵母工程有关。该项目应为研究界提供重要的新发现，产生研究引用，并通过培训员工和学生为高技能劳动力做出贡献。

This project aims to discover how cells regulate ribosome function and selectivity, by modifying their ribosomal proteins. This affects protein synthesis, a process which is central to the growth of all living things. Expected outcomes include new knowledge on the regulation of protein synthesis, improved techniques for the study of this process and an enhanced capacity for international collaboration. New avenues for the artificial regulation of the ribosome may also emerge, relevant to synthetic biology and the engineering of industrial yeasts. The project should provide significant new findings for the research community, generate research citations and contribute to a highly skilled workforce by the training of staff and students.