Study of retrovirus-specific T cell responses in Sjogren syndrome.

逆转录病毒在干燥综合征（SS）发病机制中的可能作用已被提出。然而，证据一直是间接的，并且根本不知道对逆转录病毒的细胞免疫应答是否与疾病的机制有关。虽然SS唾液腺中T淋巴细胞的寡克隆扩增已通过T细胞受体使用的分析表明，但相应的配体是未知的。一个重要的问题是，这种疾病是否涉及病毒特异性免疫攻击的唾液组织，这可能是一个网站的逆转录病毒潜伏期。我们介绍了我们独特的功能研究唾液腺浸润T淋巴细胞在SS患者检测逆转录病毒特异性记忆T淋巴细胞。我们的研究结果表明，病变中逆转录病毒特异性免疫反应的状态与疾病没有潜在的联系。我们也没有发现任何证据表明逆转录病毒感染的唾液组织中的SS患者。

The possible role of retroviruses in the pathogenesis of Sjogren's syndrome (SS) has been suggested. However, the evidence has been circumstantial and it is not known at all whether cellular immune responses to retroviruses are linked to the mechanism of the disease. Although the oligoclonal expansion of T lymphocytes in salivary glands of SS has been indicated by analyzes of T cell receptor usage, the corresponding ligands are unknown. An important question is of whether this disorder involves virus specific immune attaks on the salivary tissue which may be a site for retroviruses latency. We introduced our unique functional study of the salivary gland-infiltrating T lymphocytes in patients with SS for detecting retrovirus specific memory T lymphocyts. Our results of the study suggested no potential association of the state of retrovirus-specific immune responses in the lesion with the disease. We also could not find any evidence for retrovirus infection in the salivary tissues from patients with SS.