Lessons From Nature: Late Stage Oxidation in Total Synthesis

该项目旨在实现一系列具有生物活性的新型天然产物的化学合成。关键的方面是应用受自然启发的化学，以快速的方式提供分子的复杂性，这将允许生产分子，否则无法从自然来源获得足够数量的分子。这项研究将利用中间体的后期氧化来提供容易获得的复杂分子。主要目标是开发新的化学和生物催化剂，以进一步应用于有机合成，以期生产新的药物和重要材料。

This project aims to achieve the chemical synthesis of a number of biologically active novel natural products. The key aspect is the application of chemistry inspired by Nature to deliver molecular complexity in a rapid fashion which would allow for the production of molecules otherwise unavailable in sufficient quantities from the natural sources. This research will utilize late stage oxidation of intermediates to provide ready access to complex molecules. The main goal is the development of new chemical and biological catalysts for further application in organic synthesis with a view to the production of new medicinal agents and important materials.