Randomized controlled trial in patients polypectomized for benign adenomas/polyps of the colon

癌症，包括结直肠癌，是由宿主和环境因素之间的相互作用以及基因改变的积累如癌基因的激活和抑制基因的失活引起的。癌变过程是多因素、多打击、多阶段的机制，沿着进行。结直肠癌主要通过腺瘤-癌序列进行。因此，预防结肠腺瘤/息肉似乎有利于减少癌症的发作。我们计划在因良性腺瘤/息肉而切除息肉的患者中进行随机对照试验。建议实验组患者减少整体脂肪和含n-6多不饱和脂肪酸（PUFA）的食物如植物油和用植物油烹调的食物的摄入，增加含n-3 PUFA的食物如鱼、紫苏油和鱼油的摄入。建议对照组整体减少脂肪摄入。通过测量血浆、红细胞膜和结肠正常膜中脂肪酸的浓度来检查他们的依从性。将分析生物标志物，如细胞周期/增殖标志物、COX 2相关蛋白、PGE 2水平和凋亡标志物。在适当的时候，将比较实验组和对照组之间腺瘤/息肉的复发/发作率。这项研究目前正在进行中，在遵守方面的初步结果报告在这里。

Cancer, including colorectal cancer, is caused by the interaction between host and environmental factors together with an accumulation of gene alterations such as activation of oncogenes and inactivation of suppressor genes. Carcinogenesis progresses along with multi-factor, multi-hit and multi-stage mechanisum. Colorectal cancer proceeds largely through an adenoma-carcinoma sequence. Thus, the prevention of adenomas/polyps of the colon seems beneficial for reducing the onset of the cancer. We planned a ranomized controlled trial in the patients polypectomized for benign adenomas/polyps. The patients in the experimental group were advised to decrease their intake of fat as a whole and of foods containing n-6 polyunsaturated fatty acids(PUFA) such as vegetable oil and foods cooked with it, and to increase their intake of foods containing n-3 PUFA, including fish, perilla oil and fish oil. Those in the comparison group were advised to decrease intake of fat as a whole. Their compliance will be checked by measuring the concentration of fatty acid in the plasma, membrance of red blood cells and normal membrane of the colon. Biomarkers such as cell-cycle/proliferation markers, COX2-related proteins, PGE2 level, and apoptosis markers will be analyzed. In due course, the relapsing/onset rate of adenomas/polyps will be compared between experimental and comparison groups. The study is now ongoing, and its preliminary results in terms of compliance are reported here.