400 MHz NMR Spectrometer

我们要求采购一台新的400 MHz NMR光谱仪，配有N2冷冻探头，包括超导磁体、控制台、样品交换器和温度控制单元，用于在可变温度（VT）下进行测量。该仪器将取代两台200兆赫核磁共振波谱仪（采购年份：1987年和2001年）。由于容易发生故障、缺乏维修设施、软件过时和场强低，拟更换的仪器已不再实用。过时的电子学和缺乏梯度选择实验阻碍了当代分子化学结构分析。与此同时，由于新任命，教师中的样本数量大量增加。现有的NMR光谱仪（参见使用概念）无法满足常规测量以及更长时间测量的需求，例如在可变温度或动力学研究中。拟议的光谱仪将作为一个“步入式”常规仪器进行操作，用于测量大量样品，冷冻探头确保对各种NMR活性核的高灵敏度。参与的研究小组使用液相NMR光谱作为核心分析方法。这导致有时每天>100次测量的样本量。新仪器的典型应用将是具有高至中等灵敏度的核的一维和二维测量，例如1H，2H，13C，15N，19F，29Si，31P，11B，119Sn，7Li。特别是，通过为仪器配备低温样品头，将大大增强对29 Si等灵敏度较低的核的测量，并将提供对反应中间体结构化学的深入了解。同样，该仪器将用于测量反应动力学和分子动力学，从而在阐明主要基于主族元素的系统的反应机制领域做出决定性贡献。除了无机化学研究所和有机化学研究所的研究小组外，该仪器池还为物理化学研究所或生物化学研究所的工作组提供服务。新仪器通过在线预订系统和高效的进样器灵活预订测量时间，因此可以全天候协调常规操作或计划的更长时间测量中的大量样品。

We request the procurement of a new 400 MHz NMR spectrometer with N2 cryo-probe head including superconducting magnet, console, sample changer and temperature control unit for measurements at variable temperature (VT). The instrument will replace two 200 MHz NMR spectrometers (years of procurement: 1987 and 2001). The instruments to be replaced are no longer practical due to high susceptibility to faults, lack of repair facilities, outdated software and low field strength. Outdated electronics and the lack of gradient-selected experiments prevent contemporary molecular chemical structural analysis. At the same time, there is a large increase in the number of samples in the faculty due to new appointments. Existing NMR spectrometers (see utilization concept) cannot meet the demand for routine measurements as well as longer measurements, e.g. at variable temperature or kinetic studies. The proposed spectrometer will be operated as a "walk-in" routine instrument for the measurement of a large number of samples, with the cryo-probe head ensuring high sensitivity for a variety of NMR-active nuclei. The research groups involved use liquid-phase NMR spectroscopy as the core analytical method. This results in a sample volume of sometimes >100 measurements per day. The typical application of the new instrument will be the 1D and 2D measurement of nuclei with high to medium sensitivity, such as 1H, 2H, 13C, 15N, 19F, 29Si, 31P, 11B, 119Sn, 7Li. In particular, the measurement of less sensitive nuclei such as 29Si will be greatly enhanced by equipping the instrument with the cryo-sample head, and will provide insights into the structural chemistry of reaction intermediates as well. Likewise, the instrument will be used to measure reaction kinetics and molecular dynamics, and thus contribute decisively in the field of elucidating reaction mechanisms of predominantly main group element-based systems. Besides the research groups at the Inorganic-Chemical and the Organic-Chemical Institute, also working groups e.g. from the Physical-Chemical Institute or from Biochemistry are served by this instrument pool. The new instrument is operated by flexibly bookable measurement times via an online booking system and an efficient sample changer, so that numerous samples in routine operation or planned longer measurements can be coordinated 24/7.