Early markers of Parkinson's disease

PD患者大脑中1MeTIQ含量的显著下降可能是由于1MeTIQ降解速率的增加和/或1MeTIQ生物合成的减少。我们的研究结果支持这样的观点，即帕金森病的内源性和外源性诱导剂确实抑制了1MeTIQ的生物合成，而1MeTIQ通过一种未知的机制具有预防帕金森病的作用。我们的发现也与一篇报道一致，即在mptp处理的C57BL/6小鼠大脑中，1MeTIQ含量降低。去戊烯醇可以降低1BnTIQ（一种帕金森病包括化合物）的含量，增加1MeTIQ（一种帕金森病保护化合物）的含量。1BnTIQ含量与1MeTIQ含量的平衡可能非常重要，特别是在PD患者的纹状体和黑质中。针对上述机制的抗帕金森药物的开发是值得期待的。

The significant decrease in 1MeTIQ content in the brain of PD patients may be due to an increase in the rate of degradation of 1MeTIQ and/or a decrease of 1MeTIQ biosynthesis. Our results support the idea that endogenous and exogenous inducers of parkinsonism do inhibit the biosynthesis of 1MeTIQ, which bas a parkinsonism-preventive effect via an unknown mechanism. Our findings are also consistent with a report that the 1MeTIQ content is decreased in MPTP-treated C57BL/6 mouse brain. Deprenyl can reduce the content of 1BnTIQ (a parkinsonism-including compound) and increase the content of 1MeTIQ (a parkinsonism-protective compound). The balance of 1BnTIQ content to 1MeTIQ content may be very important especially striatum and substantia nigra of PD patients. Development of the anti-parkinsonian drug for above mentioned mechanism is desirable.