Organic Chemistry of Nitric Oxide for the Understanding of Its Physiological Roles

它的简单结构，硝酸氧化物（不）已经找到可以在生物系统中发挥多样性作用的方法。由于积极的生理学角色，没有导致身体在某一情况下受到更大的伤害，因为“NO”在相对较高的集中程度上被释放。在这些循环中，“NO”是由各种活性氧化物的反应作用激活的，以产生更多的反应性氮氧化物，并且在该过程中已经成为毒理学研究的一个重要目标。因为根据化学氧化物的反应性物种向有机分子发展，我们最近已经研究了化学氧化物与氮化合物的反应作用，在氧化物的存在和缺失，在这个系统中发现了两种氧气角色，一种是，氧气中的一种被认为是氧化物测量仪，以及催化剂中的其他氧气功能。有了这些结果，我们下一个应用反应系统来开发一种新的硝酸氧化物测序方法，并找到了N-氨基氮杂氮杂学快速反应的情况下，在数量年中，氧气的各种剂量与电荷对应的消除产品。NO or higher nitrogen oxides was transformed stoichiometrically to nitrous oxide NイイD22イエD2O.在补充中，N-氨基唑衍生物也找到了某些超氧化物阴离子，它是过氧化物酶的前体和其他活性氧化物物种。

Despite its simple structure, nitric oxide (NO) has been found to play diverse roles in biological systems. Accompanied by the positive physiological roles, NO causes extensive damage to the body in the case that NO is released at relatively higher concentration. In these circumstances, NO is activated by the reaction with various active oxygens to afford more reactive nitrogen oxides, and the ultimate reactive species included in the processes has been an important target for toxicological studies.For the understanding of reactive species of nitrogen oxides toward organic molecules, we have recently been studying the reaction of nitric oxide with nitrogen compounds in the presence and absence of oxygen, and found that oxygen plays two type of roles in this system, that is, one in which oxygen is consumed according to a stoichiometry, and the other where oxygen functions in a catalytic manner. With these results in hand, we next applied the reaction system to development of a new methodology of nitric oxide quenching, and found that N-aminoazaaromatics reacted rapidly with NO in the presence of various amounts of oxygen to afford corresponding deaminated products in quantitative yields. NO or higher nitrogen oxides was transformed stoichiometrically to nitrous oxide NィイD22ィエD2O. In addition, N-aminoazole derivatives were also found to quench superoxide anion, which is a precursor of peroxynitrite and other active oxygen species.