Ultrasonic wave assisted micro bubble manipulation and it application

直径在几微米或更小的微气泡在医疗诊断和医疗领域引起了人们的关注。这项研究的研究代表正在报告其在过去几年中可能询问的关于超声波操纵颗粒的结果。在本研究中，基于这些结果，本研究获得了以下结果。1)充分利用模拟的细胞动力学评价。2)详细的实验考核，从基础实验到动物实验。3)基于这些知识开发新的应用程序。具体成果如下。1)在数值分析方面，编制了考虑蜂窝薄膜表面张力影响的三维完整模型的程序。2)分析了存在两个或多个气泡的情况下气泡的非线性振动。在实验室现有超声波发射系统的基础上，研制了可同时发射四个独立超声波的实验系统。考察了红细胞对细胞捕集的影响，利用气泡对细胞动力学进行了详细的研究。

Micro air bubbles with a diameter of several micrometers or less attract attention in the field of a medical diagnosis and medical treatment. The research representative of this research is reporting the result in which it might inquire over the past several years about manipulation of the particle by the ultrasonic wave. In this research, the following results were obtained based on these results. 1) The evaluation of cellular dynamics which made full use of a simulation. 2) Detailed experimental examination containing from a basic experiment to an animal experiment. 3) Development of the new application based on these knowledge. The concrete results are follows. 1) About numerical analysis, the code in the 3-dimensional completeness model in consideration of the influence of the surface tension of a cellular film is completed. 2) It analyzed about nonlinear vibration of the air bubbles in the case where two or more air bubbles exist. The experimental system which can transmit four independent ultrasonic waves simultaneously based on a laboratory existing ultrasonic transmitting system was made. Examination about the influence erythrocyte affects cellular trapping, research of detailed cellular dynamics using the air bubbles were done.