Development of efficient organic reactions utilizing microspace

(1)聚合物固定化金属催化剂在微通道反应器中催化反应的研究进展作者已经通过在微通道反应器内壁固定化原始聚合物钯催化剂，开发了微通道反应器中气-液-固三相加氢反应。在这个项目中，其他聚合物催化剂如钪、钌和金被开发并应用于各种反应，如Lewis酸催化反应，利用分子氧的三相氧化。反应以高收率进行。聚硅烷在三相加氢反应中也是一种有效的聚合物。(2)利用微通道反应器进行高效催化反应，将聚硅烷负载的钯催化剂固定在微通道反应器内壁上，进行三相加氢反应。微通道反应器可连续使用长达100小时，可循环使用15次。将聚合物负载的金催化剂固定在微通道反应器内壁后，利用分子氧进行气-液-固三相醇氧化反应，得到相应的羰基化合物。另一方面，进行了大规模合成的计数实验。显著提高了加氢反应的产率。

(1) Development of polymer-immobilized metal catalysts toward catalytic reactions in microchannel reactors The author had already developed gas-liquid-solid triphase hydrogenation reactions in microchannel reactors by immobilizing original polymer palladium catalyst on the inner wall of the microchannel reactors. In this project other polymer catalysts immobilizing metals such as scandium, ruthenium, and gold were developed and applied to various reactions such as Lewis acid-catalyzed reactions, triphase oxidation using molecular oxygen. The reaction proceeded in high yield. Polysilane was also found to be effective as a polymer in triphase hydrogenation reaction.(2) Development of efficient catalytic reactions using microchannel reactors Polysilane-supported palladium catalyst was immobilized on the inner wall of microchannel reactor and triphase hydrogenation reaction was performed. The microchannel reactor could be used continuously for up to 100 hours and could be recycled 15 times. When polymer-supported gold catalyst was immobilized on the inner wall of microchannel reactor, gas-liquid-solid triphase alcohol oxidation reaction using molecular oxygen proceeded smoothly to give corresponding carbonyl compounds. On the other hand, numbering-up experiment was performed for larger scale synthesis. Productivity of hydrogenation reaction was significantly improved.