Investigation on Preventive Effects of Pregnancy Mongolian Large Intake of Dairy Products for Cleft Lip and/or Palate Incidence

1.在蒙古开展了关于唇腭裂发病率的调查。我们总共发现了23名患者：21名在偏远省份（阿尔汉盖州2名、巴彦乌列盖州1名、巴彦洪戈尔州4名、布尔干州1名、戈维阿尔泰州1名、鄂尔浑州5名、乌姆努戈维州1名、乌布苏州3名、科布多州2名、肯特州1名），以及乌兰巴托州2名。2.研究了孕前食用乳制品对唇腭裂发病率的影响，以检验乳制品的预防作用。这项研究是使用容易发生唇腭裂的A/J小鼠进行的。在怀孕前2周和怀孕期间，随意给予NJ小鼠奶酪和CA-1，CA-1是用于繁殖的常用小鼠饲料，以比较唇腭裂的发生率与非奶酪对照组。对照组仅给予CA-1饲料。研究对象组被给予奶酪和CA-1：第一组被给予在日本生产和销售的奶酪，第二组被给予在日本生产和销售的奶酪。 ...更多信息 在蒙古。从妊娠第18天剖腹产的母鼠中取出胚胎，用体视显微镜检查面部和口腔畸形。结果表明，对照组134个活胚中有11个（8.2%）为唇腭裂胚。其中腭裂6例（4.5%），唇腭裂5例（3.7%）。给予日本奶酪的137个活胚胎的第一受试者组有6个（4.4%）唇腭裂胚胎。其中腭裂2例（1.5%），唇腭裂4例（2.9%）。第二个受试组的83个活胚胎给予蒙古奶酪，有4个（4.5%）唇腭裂胚胎。腭裂0例（0.0%），唇腭裂4例（4.5%）。虽然第一组和第二组的对照组和受试者组之间没有显著差异，但给予蒙古奶酪的第二组没有腭裂病例。此外，以与上述相同的方式用小鼠进行了使用蒙古奶酪的其他样品的研究。少

1. Surveys about the incidence of cleft lip and palate were conducted in Mongolia. We found total 23 patients: 21 in remote prefectures (2 in Arkhangai Prefecture, 1 in Bayan-Ulgii, 4 in Bayankhongor, 1 in Bulgan, 1 in Govi-Altai, 5 in Orkhon, 1 in Umnugovi, 3 in Uvs, 2 in Khovd, and 1 in Khentii), and 2 in Ulaanbaatar Prefecture.2. Effects of dairy products taken before pregnancy on the incidence of cleft lip and palate were studied to examine preventive effects of dairy products. The study was conducted using A/J mice that develop cleft lip and palate easily. The NJ mice were given cheese and CA-1 that is a common mouse-feed for breeding ad libitum 2 weeks before pregnancy and during pregnancy to compare the incidence of cleft lip and palate with control groups of non-cheese. The control groups were given only CA-1 feed. The subject groups were given cheese and CA-1: the first subject groups were given cheese made and sold in Japan and the second subject groups were given cheese made … More in Mongolia. An embryo was taken from a dam with Caesarean operation on the day 18 of pregnancy to examine facial and oral abnormalities with a stereoscopic microscope. The result was that the control groups of 134 living embryos had 11 (8.2%) cleft lip and palate embryos. Of them, 6 (4.5%) was cleft palate and 5 (3.7%) was cleft lip and palate. The first subject groups of 137 living embryos given Japanese cheese had 6 (4.4%) cleft lip and palate embryos. Of them, 2 (1.5%) was cleft palate and 4 (2.9%) was cleft lip and palate. The second subject groups of 83 living embryos given Mongolian cheese had 4 (4.5%) cleft lip and palate embryos. Of them, 0 (0.0%) was cleft palate and 4 (4.5%) was cleft lip and palate. Although there was no significant difference between the control groups and subject groups of either the first or the second, the second groups given Mongolian cheese had no cleft palate case. Further, studies using other samples of Mongolian cheese were conducted with mice in the same way as the above. Less