Cellular characteristics and clinical assessment of breast cancer using F-18 FDG-PET

118例女性患者（年龄28-91岁）122处疑似乳腺癌病变，行氟-18氟脱氧葡萄糖PET （^<18 b> F-FDG）术前分期。获得全身图像后，进行俯卧位乳房PET成像。将两幅图像的结果与组织病理学结果进行比较。采用敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和准确性来比较俯卧位乳房PET图像与全身PET图像的诊断准确性。全身PET图像的敏感性、特异性、PPV、NPV和准确性分别为83%、50%、97%、17%和80%，俯卧位乳房PET图像的敏感性、特异性、NPV和准确性分别为95%、50%、96%、43%和93%。114例乳腺癌病变中有10例（8.8%）仅在俯卧位乳腺PET图像上被发现。俯卧位乳腺PET图像的灵敏度、准确性、NPV与全身PET图像的灵敏度、准确性、NPV差异均有统计学意义（P < 0.0001， NPV值P < 0.0009）。总之，我们关于122个疑似乳腺癌病变的数据，关于俯卧位乳房PET成像的有用性，表明俯卧位乳房PET图像在检测乳腺癌方面是有效的。在乳腺癌细胞增殖方面，我们评估了ERK MAPK与FDG-PET获得的SUVmax之间的关系。不幸的是，免疫组织病理学获得的ERK MAPK与SUVmax之间没有相关性。我们的结果数据表明，乳腺癌细胞增殖需要在FDG-PET研究中选择未来的过程。

One hundred eighteen female patients (age range 28-91 years) with 122 lesions suspected of having breast cancer underwent fluorine-18 fluorodeoxyglucose (^<18>F-FDG) PET for preoperative staging. After the whole-body image was acquired, prone breast PET imaging was performed. The findings from both images were compared with the histopathologic results. Sensitivity, specificity, positive predictive values (PPV), negative predictive values (NPV), and accuracy were used to compare the diagnostic accuracy of prone breast PET images with that of whole-body PET images. Sensitivity, specificity, PPV, NPV, and accuracy of whole-body PET images were 83%, 50%, 97%, 17%, and 80%, and for prone breast PET images were 95%, 50%, 96%, 43%, and 93%. Ten of 114 breast cancerous lesions (8.8%) were detected on prone breast PET images alone. There was statistical difference between the sensitivity, accuracy, and NPV of prone breast PET images and, those of whole-body PET images (P < 0.0001 for sensitivity and accuracy, and P < 0.0009 for NPV). In conclusion, our data regarding the 122 lesions suspected of breast cancer with regard to the usefulness of prone breast PET imaging indicate that prone breast PET images are effective in detecting breast cancer.With respect to cell proliferation in breast cancer, we evaluated the relationship between ERK MAPK and SUVmax obtained by FDG-PET. Unfortunately, there was no correlation between ERK MAPK obtained by immunohistopathology and SUVmax. Our resultant data addressed that cell proliferation in breast cancer is need to choose the future course in the FDG-PET study.