Immuno-genetics on Mongoloid in Pan-Pacific and Northland Areas

为了建立全面的蒙古人种传播信息，我们研究了近二十年来蒙古人种中肿瘤病毒的民族流行病学特征和免疫遗传特征。为了分析htlv -1的地理和种族分布以及人类白细胞抗原（HLA）和脂肪代谢产物的遗传多态性模式，本研究以加拿大北部和东格陵兰岛（丹麦）的200名因纽特人为研究对象。根据上述目的，我们计划在土著人定居的冬季（1月至2月）进行实地工作。2006年，我们计划与温哥华大学合作，在加拿大北部育空地区对因纽特人进行实地考察，但最终未能获得不列颠哥伦比亚省政府当局对采集土著居民血液样本的正式许可。相反，我们对600名爱知县日本人的HLA亚型（DR， DP， DQ）频率进行了研究，以比较世界范围内蒙古人的特征分布。2007年，我们把重点放在丹麦东格陵兰岛的因纽特人身上，并对伊托科托米特的100-200人进行了一次实地工作，采集了血液样本，但由于格陵兰当局的阻止，我们不得不放弃采集血样。现在，我们正在与丹麦研究人员谈判合作，他们在过去几年里从同一地区的因纽特人身上收集了血液样本。另一方面，我们已经建立了淋巴细胞库（Sonoda-Tajima Collection），这些淋巴细胞库是我们在过去20年里在RIKEN研究所生物资源中心收集的，与本研究有关，用于这些有价值的材料的多用途使用。我们收集了HTLV-I在蒙古人种中的全球分布及其免疫遗传特征的综合信息。

To contribute to the establishment of comprehensive information on worldwide Mongoloid dispersal, we have studied ethnoepidemiologic features of tumour viruses and immuno-genetic characteristics among Mongoloids during the last twenty years. To analyze geographic and ethnic distribution of HTLV-1and genetic polymorphism patterns of human leucocyte antigen (HLA) and fat metabolites among Mongoloid people in Northland areas in the present study, we focused on 200 Inuit people in North Canada and East Greenland (Denmark). We projected field works in winter season (January of February) when indigenous people settle down in one place according to the mentioned above purposes. In 2006 we planned a field work on Inuit people in Yukon area, North Canada in collaboration with University of Vancouver, but we finally could not get official permission of collecting blood samples from indigenous people from the authority of British Columbian Government. Instead of it, we invested HLA subtypes (DR, DP, DQ) frequency among 600 Japanese people in Aichi Prefecture to compare characteristic distribution among worldwide Mongoloids people. In 2007 we focused on Inuit people in East Greenland, Denmark and conducted a field work to collect blood samples from 100-200 people in Ittoqqortoormiit, but we had to obliged giving up collecting blood samples because of order to stop from the Greenland authority. Nowadays we are negotiating collaboration with Danish researchers who have collected blood samples from Inuit people in the same area during the last several years. On the other hand we have established lymphocytes bank (Sonoda-Tajima Collection) of worldwide Mongoloid people which we collected during the last 20 years linked with the present study, at the Bio-resource Center, RIKEN Institute for multipurpose usage of those valuable materials. We put together comprehensive information on worldwide distribution of HTLV-I among Mongoloids and their immuno-genetic characteristics.