Roles of prostanoids in the pathogenesis of cardiovascular diseases
Roles of prostanoids in the pathogenesis of cardiovascular diseases
批准号:
19390060
负责人:
USHIKUBI Fumitaka
金额:
$11.81万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
我们打算通过缺乏前列腺素受体的小鼠和心血管疾病的小鼠模型来阐明前列腺素在心血管疾病发病机制中的作用。阐明了PGE_2的心脏保护作用和PGI_2对血管重构的抑制作用。我们还发现PGE_2通过EP4受体具有抗血小板作用。
英文摘要
We intended to clarify the roles of prostanoids in the pathogenesis of cardiovascular diseases using mice lacking each prostanoid receptor and murine model of cardiovascular diseases. We clarified the cardioprotective effect of PGE_2 and the suppressive effect of PGI_2 on vascular remodeling. We also found an anti-platelet effect of PGE_2 via EP4 receptor.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI:
--
发表时间:
2010-04
期刊:
International angiology : a journal of the International Union of Angiology
影响因子:
--
作者:
[Koh-ichi Yuhki;H. Kashiwagi;Fumiaki Kojima;J. Kawabe;F. Ushikubi]
通讯作者:
Koh-ichi Yuhki;H. Kashiwagi;Fumiaki Kojima;J. Kawabe;F. Ushikubi
Prostaglandin I2 Promotes Recruitment of Endothelial Progenitor Cells and Limits Vascular Remodeling
DOI:
10.1161/atvbaha.109.193730
发表时间:
2010-03-01
期刊:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
影响因子:
8.7
作者:
[Kawabe, Jun-ichi, Yuhki, Koh-ichi, Ushikubi, Fumitaka]
通讯作者:
Ushikubi, Fumitaka
Regulation of cardiac prostanoid synthesis by glucocorticoid and its pathophysiological meaning
-
批准号:25670124
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2013
-
负责人:USHIKUBI Fumitaka
-
依托单位:
Roles of the prostanoids in the regulation of immunological responses
-
批准号:23659130
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2011
-
负责人:USHIKUBI Fumitaka
-
依托单位:
Roles of the prostanoids in the pathogenesis of cardiovascular diseases
-
批准号:22390045
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.9万
-
财政年份:2010
-
负责人:USHIKUBI Fumitaka
-
依托单位:
Roles of prostanoids in cardiovascular system revealed from studies using knockout mice
-
批准号:14370049
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.41万
-
财政年份:2002
-
负责人:USHIKUBI Fumitaka
-
依托单位:
Identification of the receptor, which mediates the tumor promoting effect of prostanoids, using knock-out mice.
-
批准号:11138202
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas (A)
-
资助金额:$6.4万
-
财政年份:1999
-
负责人:USHIKUBI Fumitaka
-
依托单位:
Roles of prostanoids in cardiovascularsystem revealed from studies using knockout mice
-
批准号:11470020
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.34万
-
财政年份:1999
-
负责人:USHIKUBI Fumitaka
-
依托单位:
Physiological and Pathophysiological roles of prostanoids revealed from studies using mice lacking their receptors
-
批准号:11694269
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.22万
-
财政年份:1999
-
负责人:USHIKUBI Fumitaka
-
依托单位:
Generation and analysis of mice lacking the prostanoid receptor
-
批准号:07557175
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$9.92万
-
财政年份:1995
-
负责人:USHIKUBI Fumitaka
-
依托单位:
Analysis of the signal transduction pathway through the thromboxane A_2 receptor using the receptor-G-protein reconstitution system
-
批准号:05670121
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1993
-
负责人:USHIKUBI Fumitaka
-
依托单位:
海外基金