Roles of the prostanoids in the pathogenesis of cardiovascular diseases
Roles of the prostanoids in the pathogenesis of cardiovascular diseases
批准号:
22390045
负责人:
USHIKUBI Fumitaka
金额:
$11.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
为了阐明前列腺素在心血管系统中的作用,我们采用了几个动物模型,显示出与人类疾病相似的病理生理学。通过对这些动物模型的分析,我们发现了前列腺素类化合物的新作用,包括EP4和IP在肾间质纤维化发展中的作用,EP1在顺铂诱导的肾病发展中的作用以及ONO1301对血小板聚集的有效抑制作用。
英文摘要
To clarify the roles of the prostanoids in the cardiovascular system, we employed several animal models showing similar pathophysiology with those seen in human diseases. Through the analysis of these animal models, we found novel actions of the prostanoids, which include the role of the EP4 and IP in the development of renal interstitial fibrosis, the role of the EP1 in the development of cisplatin-induced nephropathy and the potent inhibitory action of ONO1301 on platelet aggregation._4 Au
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DOI:
10.1007/s00535-012-0718-5
发表时间:
2013-08
期刊:
Journal of Gastroenterology
影响因子:
6.3
作者:
[Md. Rafiqul Islam Khan;A. Anisuzzaman;S. Semba;Yanju Ma;Junsuke Uwada;H. Hayashi;Yuichi Suzuki;T. Takano;H. Ikeuchi;M. Uchino;A. Maemoto;F. Ushikubi;I. Muramatsu;T. Taniguchi]
通讯作者:
Md. Rafiqul Islam Khan;A. Anisuzzaman;S. Semba;Yanju Ma;Junsuke Uwada;H. Hayashi;Yuichi Suzuki;T. Takano;H. Ikeuchi;M. Uchino;A. Maemoto;F. Ushikubi;I. Muramatsu;T. Taniguchi
17β-Estradiol is critical for the preovulatory induction of prostaglandin E2 synthesis in mice.
17β-雌二醇对于小鼠排卵前诱导前列腺素 E2 合成至关重要。
DOI:
10.1016/j.mce.2012.06.006
发表时间:
2012
期刊:
Molecular and Cellular Endocrinology
影响因子:
4.1
作者:
[Toda K, Ono M, Yuhki K, Ushikubi F, and Saibara T.]
通讯作者:
and Saibara T.
DOI:
10.2492/inflammregen.31.157
发表时间:
2011-03
期刊:
Inflammation and regeneration
影响因子:
8.1
作者:
[Kojima F, Matnani RG, Kawai S, Ushikubi F, Crofford LJ]
通讯作者:
Crofford LJ
DOI:
10.1253/circj.cj-12-0897
发表时间:
2013-04-01
期刊:
CIRCULATION JOURNAL
影响因子:
3.3
作者:
[Aburakawa, Yoko, Kawabe, Jun-ichi, Hasebe, Naoyuki]
通讯作者:
Hasebe, Naoyuki
DOI:
10.1038/ki.2012.115
发表时间:
2012-07-01
期刊:
KIDNEY INTERNATIONAL
影响因子:
19.6
作者:
[Nakagawa, Naoki, Yuhki, Koh-ichi, Ushikubi, Fumitaka]
通讯作者:
Ushikubi, Fumitaka
共 10 条
Regulation of cardiac prostanoid synthesis by glucocorticoid and its pathophysiological meaning
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批准号:25670124
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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Roles of prostanoids in the pathogenesis of cardiovascular diseases
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依托单位:
Identification of the receptor, which mediates the tumor promoting effect of prostanoids, using knock-out mice.
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批准号:11138202
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas (A)
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资助金额:$6.4万
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依托单位:
Roles of prostanoids in cardiovascularsystem revealed from studies using knockout mice
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依托单位:
Physiological and Pathophysiological roles of prostanoids revealed from studies using mice lacking their receptors
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批准号:11694269
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.22万
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依托单位:
Generation and analysis of mice lacking the prostanoid receptor
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批准号:07557175
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$9.92万
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财政年份:1995
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依托单位:
Analysis of the signal transduction pathway through the thromboxane A_2 receptor using the receptor-G-protein reconstitution system
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批准号:05670121
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1993
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依托单位:
海外基金