Roles of the prostanoids in the pathogenesis of cardiovascular diseases

前列腺素在心血管疾病发病机制中的作用

• 批准号: 22390045
• 负责人: USHIKUBI Fumitaka
• 金额: $ 11.9万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390045/
• 关键词: プロスタノイド; プロスタグランジン; トロンボキサン; 循環器; 循環器系疾患; 循環器疾患; 心筋梗塞; 腎線維化; 脳血栓; 血小板

To clarify the roles of the prostanoids in the cardiovascular system, we employed several animal models showing similar pathophysiology with those seen in human diseases. Through the analysis of these animal models, we found novel actions of the prostanoids, which include the role of the EP4 and IP in the development of renal interstitial fibrosis, the role of the EP1 in the development of cisplatin-induced nephropathy and the potent inhibitory action of ONO1301 on platelet aggregation._4 Au

为了阐明前列腺素类在心血管系统中的作用，我们采用了几种动物模型，其病理生理学与人类疾病中的病理生理学相似。通过对这些动物模型的分析，我们发现了前列腺素的新作用，包括EP4和IP在肾间质纤维化发展中的作用、EP1在顺铂肾病发展中的作用以及ONO1301对血小板聚集的有效抑制作用。_4 Au

项目成果

M1 is a major subtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells

• DOI: 10.1007/s00535-012-0718-5
• 发表时间: 2013-08
• 期刊: Journal of Gastroenterology
• 影响因子: 6.3
• 作者: Md. Rafiqul Islam Khan;A. Anisuzzaman;S. Semba;Yanju Ma;Junsuke Uwada;H. Hayashi;Yuichi Suzuki;T. Takano;H. Ikeuchi;M. Uchino;A. Maemoto;F. Ushikubi;I. Muramatsu;T. Taniguchi

Potential roles of microsomal prostaglandin E synthase-1 in rheumatoid arthritis.

• DOI: 10.2492/inflammregen.31.157
• 发表时间: 2011-03
• 期刊: Inflammation and regeneration
• 影响因子: 8.1
• 作者: Kojima F;Matnani RG;Kawai S;Ushikubi F;Crofford LJ
• 通讯作者: Crofford LJ

17β-Estradiol is critical for the preovulatory induction of prostaglandin E2 synthesis in mice.

17β-雌二醇对于小鼠排卵前诱导前列腺素 E2 合成至关重要。

• DOI: 10.1016/j.mce.2012.06.006
• 发表时间: 2012
• 期刊: Molecular and Cellular Endocrinology
• 影响因子: 4.1
• 作者: Toda K;Ono M;Yuhki K;Ushikubi F;and Saibara T.
• 通讯作者: and Saibara T.

Prostacyclin Stimulated Integrin-Dependent Angiogenic Effects of Endothelial Progenitor Cells and Mediated Potent Circulation Recovery in Ischemic Hind Limb Model

• DOI: 10.1253/circj.cj-12-0897
• 发表时间: 2013-04-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Aburakawa, Yoko;Kawabe, Jun-ichi;Hasebe, Naoyuki
• 通讯作者: Hasebe, Naoyuki

The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice

• DOI: 10.1038/ki.2012.115
• 发表时间: 2012-07-01
• 期刊: KIDNEY INTERNATIONAL
• 影响因子: 19.6
• 作者: Nakagawa, Naoki;Yuhki, Koh-ichi;Ushikubi, Fumitaka
• 通讯作者: Ushikubi, Fumitaka