Selection of malaria protective sera useful for novel vaccine candidate discovery

生活在疟疾流行地区的个体反复接触疟原虫，逐渐对感染的临床表现产生免疫。这种对临床疾病的抵抗力部分是由针对疟原虫无性血阶段的抗体介导的。为了识别这些携带保护性抗体的个体，我们筛选了对未来候选疫苗发现有用的人血清标本。在泰国西部的流行村庄进行了三年监测后，我们成功地获得了无症状血清和有症状患者血清作为阴性对照。

The individuals live in malaria endemic area who repeatedly exposed to the malaria parasite gradually develop immunity to the clinical manifestations of infection. This resistance to clinical disease is partly mediated by antibodies against the asexual blood stages of the malaria parasite. To identify such individuals harboring protective antibodies we have screened the human serum specimen useful for the future vaccine candidate discovery. After three-years surveillance in the endemic village in western Thailand, we have successfully obtained both asymptomatic sera and symptomatic patient sera as negative controls.