Clinicopathological role of kl-6/muc1 with selectin ligand

KL-6/MUC1是间质性肺炎的敏感生物标志物。我们发现KL-6/ muc1粘蛋白带有选择素配体（称为SLAK）。在ARDS患者中SLAK明显升高。此外，SLAK被发现是ARDS中DIC并发症的敏感、特异性和独立的预测因子。因此，在诊断时测量SLAK水平可以准确预测ARDS中DIC的未来并发症。对于SLAK水平升高的患者，早期干预低分子肝素等抗dic药物可改善ARDS预后，目前ARDS预后极差。

KL-6/MUC1 is a sensitive biomarker for interstitial pneumonias. We found KL-6/MUC1mucins with selectin ligand (designated as SLAK). SLAK was found to be significantly elevated in ARDS patients. Furthermore, SLAK was discovered to be a sensitive, specific and independent predictor for DIC complication in ARDS. Therefore, measurement of SLAK level at diagnosis may be able to predict accurately future complications of DIC in ARDS. Early intervention with anti-DIC medication such as low-molecular-weight heparin in the patients with elevated level of SLAK may improve the prognosis of ARDS, which is currently extremely poor.