Tracking the intracellular dynamics of HIV-1 proteins

人类免疫缺陷病毒1型（HIV-1）利用受感染宿主细胞的大分子机制产生子代病毒。我们已经确定了细胞因子信号转导抑制因子1（SOCS 1）作为宿主因子，积极调节细胞内运输和HIV-1 Gag的稳定性。SOCS 1可以直接与Gag结合并增强其稳定性和运输，从而有效地产生HIV-1颗粒。我们还发现SOCS 1可以增强Gag的泛素化并促进其与微管网络的相互作用。这些发现将有助于开发新的抗HIV治疗方法。

Human immunodeficiency virus type 1 (HIV-1) utilizes the macromolecular machinery of the infected host cell to produce progeny virus. We have identified suppressor of cytokine signaling 1 (SOCS1) as a host factor that positively regulates the intracellular trafficking and stability of HIV-1 Gag. SOCS1 can directly bind to Gag and enhance its stability and trafficking, resulting in the efficient production of HIV-1 particles. We found also that SOCS1 can enhance the ubiqtuitintion of Gag and facilitate its interaction with microtubule network. These findings will be useful for developing a new anti-HIV therapy.